دواعي استعمال Thiotacid Compound 600 mg

Thiotacid Compound 600 mg: oral film-coated caplets combining thioctic (alpha-lipoic) acid 600 mg with vitamin B1 and vitamin B12, by EVA Pharma (Egypt).

• Symptomatic diabetic peripheral neuropathy (evidence from IV and oral trials; approved for this use in Germany per LPI)الفئة: Adults with diabetesLinus Pauling Institute, Oregon State University

• Most frequently reported side effects of oral lipoic acid are allergic skin reactions (rash, hives, itching); abdominal pain, nausea, vomiting, diarrhoea and vertigo have also been reported, with nausea, vomiting and vertigo dose-dependent in one trial.معلومة عامة عن المادة الفعالة · Linus Pauling Institute, Oregon State University
• Malodorous urine has been noted with oral lipoic acid 1,200 mg/day.معلومة عامة عن المادة الفعالة · Linus Pauling Institute, Oregon State University

• Accidental ingestion of four 600 mg tablets by a 20-month-old child caused seizures, acidosis and unconsciousness; a fatal non-accidental overdose in an adolescent has been reported. Keep out of reach of children.معلومة عامة عن المادة الفعالة · Linus Pauling Institute, Oregon State University
• Rare anaphylactoid/anaphylactic reactions have been reported after intravenous lipoic acid.معلومة عامة عن المادة الفعالة · Linus Pauling Institute, Oregon State University
• Use with caution under medical supervision in pregnancy/breastfeeding and in diabetes (insulin/antidiabetic dose adjustment) (retailer product text).حسب الشركة المنتجة

• Insulin and oral antidiabetic agentsPossible additive hypoglycaemia; monitor blood glucose. A single-dose study found no significant interaction with glyburide or acarbose.Linus Pauling Institute, Oregon State University
• BiotinStructural similarity; high lipoic acid concentrations may compete with biotin for membrane transport (clinical relevance in humans unknown).Linus Pauling Institute, Oregon State University

• Limited retrospective observational data (600 mg/day oral) showed no adverse effects in mothers or newborns; in the absence of further evidence, use in pregnancy only under strict medical supervision.معلومة عامة عن المادة الفعالة · Linus Pauling Institute, Oregon State University
• Safety of lipoic acid supplements during lactation has not been established; use should be discouraged.معلومة عامة عن المادة الفعالة · Linus Pauling Institute, Oregon State University

• Blood glucose should be monitored closely when lipoic acid is added to insulin or oral antidiabetic therapy because of a theoretical risk of hypoglycaemia.معلومة عامة عن المادة الفعالة · Linus Pauling Institute, Oregon State University

• حمض الثيوكتيك (حمض ألفا ليبويك): Protein-bound R-lipoic acid is a cofactor of mitochondrial dehydrogenase complexes; free lipoic acid and dihydrolipoic acid act as antioxidants and may enhance cellular glucose uptake (Linus Pauling Institute).مضاد للأكسدة؛ عامل مساعد لإنزيمات الميتوكوندريا
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