دواعي استعمال تينام 500/500مجم فيال للتسريب الوريدي

Carbapenem antibacterial powder for intravenous infusion containing imipenem 500 mg and cilastatin 500 mg per vial, marketed in Egypt by Merck Sharp & Dohme / Soficopharm.

• Lower respiratory tract infections caused by susceptible bacteriaالفئة: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)
• Urinary tract infections (complicated and uncomplicated) caused by susceptible bacteriaالفئة: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)
• Intra-abdominal infections caused by susceptible bacteriaالفئة: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)
• Gynecologic infections caused by susceptible bacteriaالفئة: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)
• Bacterial septicemia caused by susceptible bacteriaالفئة: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)
• Bone and joint infections caused by susceptible bacteriaالفئة: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)
• Skin and skin structure infections caused by susceptible bacteriaالفئة: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)
• Endocarditis caused by susceptible bacteriaالفئة: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)

• Hypersensitivity to any component of the product.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Serious, occasionally fatal hypersensitivity (anaphylactic) reactions have occurred with beta-lactams; ask about prior penicillin, cephalosporin or other beta-lactam allergy and stop the drug if an allergic reaction occurs.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Seizures and other CNS adverse experiences (confusion, myoclonus) have been reported, especially when recommended doses were exceeded and in patients with CNS disorders or renal impairment; continue anticonvulsant therapy in known seizure disorders.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhoea has been reported and may range from mild diarrhoea to fatal colitis.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Valproic acid / divalproex sodiumCarbapenems reduce valproic acid concentrations, increasing the risk of breakthrough seizures; concomitant use is generally not recommended.DailyMed (U.S. National Library of Medicine)
• GanciclovirGeneralized seizures have been reported; do not use together unless benefits outweigh risks.DailyMed (U.S. National Library of Medicine)
• ProbenecidIncreases imipenem plasma levels and half-life; concomitant use is not recommended.DailyMed (U.S. National Library of Medicine)

• Available postmarketing data are insufficient to identify a drug-associated risk of major birth defects, miscarriage or adverse maternal/fetal outcomes; animal developmental studies showed no drug-induced fetal malformations.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Bactericidal; inhibits bacterial cell wall synthesis by binding penicillin-binding proteins.
• Inhibits renal dehydropeptidase I, preventing renal metabolism of imipenem.