سعر توريزيل Torisel‏ 30مجم/1.2مل فيال 2026

Torisel 30mg/1.2ml i.v vial

دواعي استعمال توريزيل

Treatment of advanced renal cell carcinoma.DailyMed (U.S. National Library of Medicine)

الآثار الجانبيةSide effects

Most common adverse reactions (>=30%): rash, asthenia, mucositis, nausea, edema and anorexia; common laboratory abnormalities include anemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, lymphopenia, thrombocytopenia, elevated creatinine and AST.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)

Most common adverse reactions (>=30%): rash, asthenia, mucositis, nausea, edema and anorexia; common laboratory abnormalities include anemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, lymphopenia, thrombocytopenia, elevated creatinine and AST.International label, same product · DailyMed (U.S. National Library of Medicine)

موانع الاستعمالContraindications

Bilirubin >1.5x upper limit of normal.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)

Bilirubin >1.5x upper limit of normal.International label, same product · DailyMed (U.S. National Library of Medicine)

تحذيرات واحتياطاتWarnings & precautions

Hypersensitivity/infusion reactions including anaphylaxis; monitor during infusion; caution with hypersensitivity to temsirolimus, sirolimus or polysorbate 80.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)
Hyperglycemia/glucose intolerance; test serum glucose before and during treatment.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)
Immunosuppression and infections including fatal Pneumocystis jiroveci pneumonia.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)

Hypersensitivity/infusion reactions including anaphylaxis; monitor during infusion; caution with hypersensitivity to temsirolimus, sirolimus or polysorbate 80.International label, same product · DailyMed (U.S. National Library of Medicine)
Hyperglycemia/glucose intolerance; test serum glucose before and during treatment.International label, same product · DailyMed (U.S. National Library of Medicine)
Immunosuppression and infections including fatal Pneumocystis jiroveci pneumonia.International label, same product · DailyMed (U.S. National Library of Medicine)

التداخلات الدوائيةDrug interactions

Strong CYP3A4 inhibitors (e.g., ketoconazole)Sirolimus (active metabolite) AUC increased 3.1-fold and Cmax 2.2-fold; consider dose adjustment if alternative cannot be used.DailyMed (U.S. National Library of Medicine)
Strong CYP3A4 inducers (e.g., rifampin)Sirolimus Cmax decreased 65% and AUC 56%; consider dose adjustment if alternative cannot be used.DailyMed (U.S. National Library of Medicine)

Strong CYP3A4 inhibitors (e.g., ketoconazole)Sirolimus (active metabolite) AUC increased 3.1-fold and Cmax 2.2-fold; consider dose adjustment if alternative cannot be used.DailyMed (U.S. National Library of Medicine)
Strong CYP3A4 inducers (e.g., rifampin)Sirolimus Cmax decreased 65% and AUC 56%; consider dose adjustment if alternative cannot be used.DailyMed (U.S. National Library of Medicine)

الحمل والرضاعةPregnancy & breastfeeding

Based on animal studies and mechanism of action, temsirolimus can cause fetal harm; no human data on Torisel in pregnancy.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)
Do not breastfeed during treatment and for 3 weeks after the final dose.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)

Based on animal studies and mechanism of action, temsirolimus can cause fetal harm; no human data on Torisel in pregnancy.International label, same product · DailyMed (U.S. National Library of Medicine)
Do not breastfeed during treatment and for 3 weeks after the final dose.International label, same product · DailyMed (U.S. National Library of Medicine)

كيف يعمل الدواءHow it works

Binds FKBP-12; the complex inhibits mTOR activity, interfering with synthesis of proteins regulating proliferation, growth and survival of tumour cells (US Torisel label).مثبط لإنزيم mTOR

Temsirolimus: Binds FKBP-12; the complex inhibits mTOR activity, interfering with synthesis of proteins regulating proliferation, growth and survival of tumour cells (US Torisel label).

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