دواعي استعمال توريزيل 30مجم/1.2مل فيال

معلومات من نشرات دوائية ومراجع موثقة، مع مصدر كل معلومة. السعر الحالي: 6,290ج.م.

دواعي الاستعمال

الآثار الجانبية

Most common adverse reactions (>=30%): rash, asthenia, mucositis, nausea, edema and anorexia; common laboratory abnormalities include anemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, lymphopenia, thrombocytopenia, elevated creatinine and AST.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)

موانع الاستعمال

Bilirubin >1.5x upper limit of normal.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)

تحذيرات واحتياطات

Hypersensitivity/infusion reactions including anaphylaxis; monitor during infusion; caution with hypersensitivity to temsirolimus, sirolimus or polysorbate 80.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)
Hyperglycemia/glucose intolerance; test serum glucose before and during treatment.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)
Immunosuppression and infections including fatal Pneumocystis jiroveci pneumonia.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)
Interstitial lung disease, sometimes fatal; baseline and periodic lung imaging recommended.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)
Hyperlipidemia (raised triglycerides and cholesterol); check lipids before and during treatment.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)
Fatal bowel perforation, acute renal failure and impaired wound healing have been reported.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)
Embryo-fetal toxicity: can cause fetal harm; females should use effective contraception during treatment and for 3 months after the last dose.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)

التداخلات الدوائية

Strong CYP3A4 inhibitors (e.g., ketoconazole)Sirolimus (active metabolite) AUC increased 3.1-fold and Cmax 2.2-fold; consider dose adjustment if alternative cannot be used.DailyMed (U.S. National Library of Medicine)
Strong CYP3A4 inducers (e.g., rifampin)Sirolimus Cmax decreased 65% and AUC 56%; consider dose adjustment if alternative cannot be used.DailyMed (U.S. National Library of Medicine)

الحمل والرضاعة

Based on animal studies and mechanism of action, temsirolimus can cause fetal harm; no human data on Torisel in pregnancy.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)
Do not breastfeed during treatment and for 3 weeks after the final dose.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)

المتابعة أثناء العلاج

Monitor serum glucose, lipids, blood counts, renal function, respiratory symptoms with periodic chest imaging, and patients throughout each infusion.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)

كيف يعمل الدواء

Binds FKBP-12; the complex inhibits mTOR activity, interfering with synthesis of proteins regulating proliferation, growth and survival of tumour cells (US Torisel label).مثبط لإنزيم mTOR

المصادر