سعر اكتيفيز Activase‏ 50مجم 29 مليون وحدة دولية 2 فيال 2026

Activase 50 mg (29 MIU) 2 vials: alteplase (recombinant tissue plasminogen activator) 50 mg lyophilised powder for intravenous injection/infusion, hospital thrombolytic for acute ischaemic stroke, acute myocardial infarction and acute massive pulmonary embolism.

• Bleeding is the most frequent adverse reaction (>5%), including intracranial haemorrhage (higher in acute ischaemic stroke).International label, same product · DailyMed (U.S. National Library of Medicine)
• UK SmPC: bleeding in different forms with fall in haematocrit/haemoglobin; reperfusion arrhythmias in myocardial infarction.International label, same formulation · electronic medicines compendium (emc), UK

• High bleeding risk: significant bleeding disorder at present or within 6 months, haemorrhagic diathesis, manifest or recent severe bleeding, history of CNS damage, recent non-compressible vessel puncture, severe uncontrolled hypertension, bacterial endocarditis/pericarditis, acute pancreatitis, active GI ulcer disease; hypersensitivity.International label, same formulation · electronic medicines compendium (emc), UK
• US label (acute ischaemic stroke): current intracranial or subarachnoid haemorrhage, active internal bleeding, intracranial/intraspinal surgery or serious head trauma within 3 months, intracranial conditions increasing bleeding risk, bleeding diathesis, current severe uncontrolled hypertension.International label, same product · DailyMed (U.S. National Library of Medicine)

• Can cause significant, sometimes fatal, internal or external bleeding; avoid intramuscular injections and non-compressible punctures; discontinue if serious bleeding occurs.International label, same product · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity including anaphylaxis and angioedema (often with concomitant ACE inhibitors); monitor during and for several hours after infusion.International label, same product · DailyMed (U.S. National Library of Medicine)
• Thromboembolism (re-embolisation from lysis of deep venous thrombi in PE) and rare cholesterol embolisation.International label, same product · DailyMed (U.S. National Library of Medicine)

• Anticoagulants and antiplatelet drugs (incl. GPIIb/IIIa antagonists)Increase bleeding risk when given before, during or after alteplase; avoid in the first 24 h after treatment for acute ischaemic stroke.electronic medicines compendium (emc), UK
• ACE inhibitorsMay increase the risk of hypersensitivity reactions/angioedema.DailyMed (U.S. National Library of Medicine)

• Human data insufficient to inform drug-associated risk; alteplase was embryocidal in rabbits at clinical AMI exposure.International label, same product · DailyMed (U.S. National Library of Medicine)
• Limited data in pregnancy; in acute life-threatening disease the benefit must be weighed against potential risk.International label, same formulation · electronic medicines compendium (emc), UK
• Unknown whether excreted in human milk; consider discontinuing breast-feeding for the first 24 hours after use.International label, same formulation · electronic medicines compendium (emc), UK

• Alteplase: Serine protease that binds fibrin and converts fibrin-bound plasminogen to plasmin, producing local fibrinolysis.