سعر كوزيمولول 0.5% قطرة عين 5 مل 2022

Cusimolol 0.5% ophthalmic drops 5 ml: timolol (Rameda > Alcon). Non-selective ophthalmic beta-blocker for elevated IOP.

• Treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.Population: Adults and pediatric patients ≥2 years as labeledDailyMed (NLM)

• Most frequent: burning/stinging on instillation (~1 in 8). Also ocular irritation, bradycardia, hypotension, bronchospasm, headache, fatigue, and other systemic beta-blocker effects.International label, same formulation · DailyMed (NLM)

• Contraindicated in bronchial asthma or history thereof; severe COPD; sinus bradycardia; second/third-degree AV block; overt cardiac failure; cardiogenic shock; hypersensitivity to any component.International label, same formulation · DailyMed (NLM)

• Systemic absorption of ophthalmic beta-blockers can cause severe respiratory and cardiac reactions (including death from bronchospasm in asthmatics). Use caution in diabetes (may mask hypoglycemia), thyrotoxicosis, cerebrovascular insufficiency. Remove soft contact lenses before instillation (benzalkonium chloride); reinsert after 15 minutes.International label, same formulation · DailyMed (NLM)

• Oral beta-blockersMajorAdditive systemic and IOP-lowering beta-blockade; concomitant use of two topical ophthalmic beta-blockers is not recommended.DailyMed (NLM)
• CYP2D6 inhibitors (e.g. quinidine, SSRIs)ModeratePotentiated systemic beta-blockade (e.g. decreased heart rate, depression) reported with combined use.DailyMed (NLM)
• Oral/IV calcium antagonistsPossible AV conduction disturbance, left ventricular failure, hypotension; avoid co-administration in impaired cardiac function.DailyMed (NLM)

• No adequate well-controlled studies in pregnant women; use only if potential benefit justifies potential risk to the fetus (US label).International label, same formulation · DailyMed (NLM)
• Timolol maleate detected in human milk after oral and ophthalmic use; decide whether to discontinue nursing or the drug given potential serious adverse reactions in nursing infants.International label, same formulation · DailyMed (NLM)

• Timolol: Non-selective beta1/beta2 blocker without significant intrinsic sympathomimetic or membrane-stabilizing activity; lowers intraocular pressure (US Combigan label).