سعر ارليدا 60 مجم 120 قرص 2024

Erleada 60 mg (apalutamide) film-coated tablets, bottle of 120, by Janssen-Cilag (distributed by Soficopharm, Egypt).

• Metastatic castration-sensitive prostate cancer (mCSPC).Population: Adult menDailyMed (U.S. National Library of Medicine)
• Non-metastatic castration-resistant prostate cancer (nmCRPC).Population: Adult menDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (≥ 10%): fatigue, arthralgia, rash, decreased appetite, fall, weight decreased, hypertension, hot flush, diarrhoea and fracture.International label, same product · DailyMed (U.S. National Library of Medicine)

• Cerebrovascular and ischaemic cardiovascular events (including fatal events): monitor for signs and symptoms and optimise management of risk factors (hypertension, diabetes, dyslipidaemia).International label, same product · DailyMed (U.S. National Library of Medicine)
• Fractures and falls: evaluate patients for fracture and fall risk; consider bone-targeted agents.International label, same product · DailyMed (U.S. National Library of Medicine)
• Seizure (0.4% of patients): permanently discontinue in patients who develop a seizure.International label, same product · DailyMed (U.S. National Library of Medicine)

• Sensitive substrates of CYP3A4, CYP2C19, CYP2C9, UGT, P-gp, BCRP or OATP1B1Apalutamide is a strong CYP3A4 and CYP2C19 inducer and a weak CYP2C9 inducer; it can reduce exposure to these substrates and cause loss of their activity – avoid or substitute where possible.DailyMed (U.S. National Library of Medicine)
• Strong CYP2C8 or CYP3A4 inhibitorsMay increase apalutamide exposure; no initial dose adjustment, but reduce the dose based on tolerability.DailyMed (U.S. National Library of Medicine)

• Safety and efficacy not established in females. Based on its mechanism, apalutamide can cause fetal harm and loss of pregnancy; males with female partners of reproductive potential should use effective contraception during treatment and for 3 months after the last dose.International label, same product · DailyMed (U.S. National Library of Medicine)
• Not established for use in females; no data on presence in human milk.International label, same product · DailyMed (U.S. National Library of Medicine)

• Apalutamide: Binds the ligand-binding domain of the androgen receptor, inhibiting AR nuclear translocation, DNA binding and AR-mediated transcription (US Erleada label 12.1).