سعر كازودكس 50 مجم 28 قرص 2024

Bicalutamide 50 mg tablets, 28 tablets (Casodex) by AstraZeneca.

• Advanced prostate cancer, in combination with LHRH analogue therapy or surgical castrationPopulation: Adult malesDailyMed (U.S. National Library of Medicine)
• Stage D2 metastatic carcinoma of the prostate, in combination with an LHRH analoguePopulation: Adult malesDailyMed (U.S. National Library of Medicine)

• Very common: anaemia, dizziness, hot flush, abdominal pain, constipation, nausea, haematuria, gynaecomastia and breast tenderness, asthenia, oedema.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Females and children.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to bicalutamide or any excipient.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Co-administration with terfenadine, astemizole or cisapride.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Initiate under the direct supervision of a specialist.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Extensively metabolised in the liver: use with caution in moderate to severe hepatic impairment; consider periodic liver function tests (most changes occur in the first 6 months). Severe hepatic changes and hepatic failure, sometimes fatal, have been reported rarely; discontinue if changes are severe.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Coumarin anticoagulants (e.g. warfarin)Bicalutamide can displace warfarin from protein binding; increased anticoagulant effect and bleeding reported. Monitor PT/INR closely and adjust dose.DailyMed (U.S. National Library of Medicine)
• Terfenadine, astemizole, cisaprideContraindicated: R-bicalutamide inhibits CYP3A4 (midazolam AUC increased up to 80%).DailyMed (U.S. National Library of Medicine)

• Bicalutamide is contraindicated in females and must not be given to pregnant women.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Contraindicated during breast-feeding.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Bicalutamide: Competitively inhibits androgen binding to androgen receptors in target tissues.