سعر انكافاز 5/10مجم 20 قرص 2022

Fixed-dose combination film-coated tablets of amlodipine and perindopril, strength 5/10 mg (Zeta Pharma); 20 tablets per pack.

• High blood pressure (hypertension) and/or stable coronary artery disease, in patients already taking perindopril and amlodipine as separate tablets.Population: AdultsMedicines Authority Malta
• Substitution therapy for essential hypertension and/or stable coronary artery disease in patients already controlled with perindopril and amlodipine given concurrently at the same dose levelPopulation: AdultsZeta Pharma (manufacturer website)

• Very common: oedema. Common: headache, dizziness, somnolence, vertigo, paraesthesia, visual disturbance, tinnitus, palpitations, flushing, hypotension, cough, dyspnoea, gastrointestinal disorders, muscle cramps, tiredness.International label, equivalent formulation · Medicines Authority Malta

• Allergy to perindopril or any other ACE inhibitor, amlodipine or any other calcium antagonist, or any excipient; previous angioedema.International label, equivalent formulation · Medicines Authority Malta
• Pregnancy beyond the first 3 months (also better avoided in early pregnancy).International label, equivalent formulation · Medicines Authority Malta
• Severe hypotension, aortic valve stenosis or cardiogenic shock, heart failure after acute myocardial infarction, dialysis or other blood filtration, renal artery stenosis, aliskiren in diabetes or impaired kidney function, sacubitril/valsartan.International label, equivalent formulation · Medicines Authority Malta

• Stop and seek medical help immediately for swelling of face, lips, tongue or throat (angioedema), severe skin reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis), severe dizziness or fainting.International label, equivalent formulation · Medicines Authority Malta

• LithiumAvoid combination (lithium is used for mania or depression).Medicines Authority Malta
• EstramustineAvoid combination (estramustine is used in cancer therapy).Medicines Authority Malta
• Potassium-sparing diuretics (triamterene, amiloride), potassium supplements and potassium-containing salt substitutesAvoid combination (risk of raised blood potassium).Medicines Authority Malta

• Not recommended in early pregnancy and must not be taken after the third month of pregnancy (may cause serious harm to the baby).International label, equivalent formulation · Medicines Authority Malta
• Not recommended for mothers who are breast-feeding; the doctor may choose another treatment.International label, equivalent formulation · Medicines Authority Malta

• Amlodipine: Inhibits transmembrane calcium influx into vascular smooth muscle and cardiac muscle; peripheral arterial vasodilator.
• Perindopril (salt form not stated): Inhibits angiotensin-converting enzyme, reducing formation of the vasoconstrictor angiotensin II and aldosterone secretion.