سعر نورفابريل 5/10مجم 30 كبسول 2024

Amlodipine 5 mg / benazepril 10 mg capsules, pack of 30 (Marcyrl / Geopharma-Egypt); fixed-dose CCB + ACE-inhibitor combination for hypertension.

• Hypertension in patients not adequately controlled on monotherapy with either amlodipine or benazeprilPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• History of angioedema (with or without prior ACE-inhibitor treatment); hypersensitivity to benazepril, other ACE inhibitors or amlodipine; co-administration with aliskiren in patients with diabetes; within 36 hours of switching to or from sacubitril/valsartan (neprilysin inhibitor).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning - fetal toxicity: drugs acting on the renin-angiotensin system can cause fetal injury and death; discontinue as soon as pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Angioedema (head/neck and intestinal), symptomatic hypotension, worsening angina or MI on starting/increasing the dose, impaired renal function and hyperkalaemia; monitor serum potassium periodically.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Potassium-sparing diuretics and potassium supplementsIncrease the risk of hyperkalaemia; monitor serum potassium frequently.DailyMed (U.S. National Library of Medicine)
• LithiumIncreased serum lithium levels and symptoms of lithium toxicity.DailyMed (U.S. National Library of Medicine)
• NSAIDsRisk of renal dysfunction and loss of antihypertensive effect.DailyMed (U.S. National Library of Medicine)

• Can cause fetal harm: RAS-acting drugs in the second and third trimesters reduce fetal renal function and increase fetal and neonatal morbidity and death; discontinue when pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Minimal benazepril/benazeprilat passes into milk (<0.1% of the maternal dose); amlodipine is present in human milk (estimated median relative infant dose 4.2% in a published study).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Amlodipine: Inhibits transmembrane calcium influx into vascular smooth muscle and cardiac muscle; peripheral arterial vasodilator.
• Benazepril: ACE inhibitor; reduces formation of angiotensin II.