سعر اندروكور 50مجم 20 قرص 2022

Cyproterone acetate 50 mg tablets, pack of 20 (2 strips); anti-androgen.

• Control of libido in severe hypersexuality and/or sexual deviation in the adult male, when other interventions are considered inappropriate.Population: Adult maleselectronic medicines compendium (emc), UK

• Very common: reduced sperm count and ejaculate volume, infertility (reversible within months after stopping).International label, same formulation · electronic medicines compendium (emc), UK
• Common: weight changes with fluid retention, depressive mood and restlessness, dyspnoea, hepatotoxicity, gynaecomastia, hot flushes, sweating, fatigue and lassitude. Rare: meningioma, hypersensitivity, galactorrhoea.International label, same formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to cyproterone acetate or excipients; liver diseases (including Dubin-Johnson and Rotor syndromes); previous or existing liver tumours; malignant tumours (except prostate carcinoma); wasting diseases.International label, same formulation · electronic medicines compendium (emc), UK
• History of or existing thrombosis or embolism; severe diabetes with vascular changes; sickle cell anaemia; severe chronic depression.International label, same formulation · electronic medicines compendium (emc), UK
• Meningioma or a history of meningioma; youths under 18 or those with incomplete bone maturation and testicular development.International label, same formulation · electronic medicines compendium (emc), UK

• Direct hepatic toxicity (jaundice, hepatitis, hepatic failure), fatal at doses of 100 mg and above in some cases, usually several months after starting; benign and malignant liver tumours with intra-abdominal haemorrhage have occurred very rarely.International label, same formulation · electronic medicines compendium (emc), UK
• Meningiomas have been reported, primarily at doses of 25 mg and above, with risk increasing with cumulative dose; stop permanently if meningioma is diagnosed.International label, same formulation · electronic medicines compendium (emc), UK
• Thromboembolic events have been reported; patients with previous thromboembolic events, cerebrovascular accidents or advanced malignancy are at increased risk.International label, same formulation · electronic medicines compendium (emc), UK

• Thiazolidinediones (pioglitazone, rosiglitazone)At high cyproterone doses (100 mg three times daily) CYP2C8 inhibition may raise their levels; dose adjustment may be needed.electronic medicines compendium (emc), UK
• AlcoholAlcohol appears to reduce the effect of cyproterone acetate; it is of no value in chronic alcoholics.electronic medicines compendium (emc), UK
• Strong CYP3A4 inhibitors (ketoconazole, itraconazole, clotrimazole, ritonavir)Expected to inhibit the metabolism of cyproterone acetate.electronic medicines compendium (emc), UK

• Pregnancy and lactation are stated as not applicable in the UK SmPC (the 50 mg tablet is indicated only in adult men).International label, same formulation · electronic medicines compendium (emc), UK

• Cyproterone acetate: Blocks androgen receptors; its progestogenic activity exerts negative feedback on the hypothalamus, reducing gonadotrophin release and testicular androgen production (UK Androcur SmPC section 5.1).