سعر جادوفيست 1 مليمول / مل (7.5 مل) حقنة مملوءة مسبقًا 2022

Gadovist (Bayer, imported to Egypt): gadobutrol 1 mmol/mL solution for intravenous injection in a 7.5 mL single-dose prefilled syringe; a macrocyclic gadolinium-based contrast agent for MRI and MR angiography. The original listing is marked "(n/a yet)".

• MRI of the CNS to detect and visualize areas with disrupted blood-brain barrier and/or abnormal vascularityPopulation: Adults and paediatric patients including term neonatesDailyMed (U.S. National Library of Medicine)
• Breast MRI to assess the presence and extent of malignant breast diseasePopulation: AdultsDailyMed (U.S. National Library of Medicine)
• MR angiography to evaluate known or suspected supra-aortic or renal artery diseasePopulation: Adults and paediatric patients including term neonatesDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (incidence 0.5% or more): headache, nausea and dizziness.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• History of severe hypersensitivity reaction to gadobutrol (GADAVIST).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: intrathecal administration of gadolinium-based contrast agents can cause death, coma, encephalopathy and seizures; gadobutrol is not approved for intrathecal use.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: risk of nephrogenic systemic fibrosis in patients with impaired elimination (chronic severe kidney disease, GFR < 30 mL/min/1.73 m2, or acute kidney injury); avoid unless essential and screen renal function.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Anaphylactic and other hypersensitivity reactions, including fatal ones, may occur; monitor during and after administration. Gadolinium is retained for months or years in bone, brain and other organs.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• GBCAs cross the placenta; use gadobutrol in pregnancy only if imaging is essential and cannot be delayed (embryolethality in animals at 8 times the human dose).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No human milk data for gadobutrol; other GBCAs show 0.01-0.04% of the maternal dose in milk with limited infant absorption; weigh benefits of breastfeeding against maternal need.International label, same formulation · DailyMed (U.S. National Library of Medicine)

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