سعر اتينو سي 100/25 مجم 20 قرص 2025

Atenolol 100 mg + chlortalidone 25 mg tablets (beta-1 blocker plus thiazide-like diuretic, antihypertensive), pack of 20 tablets, Eipico.

• Management of hypertension.Population: Adultselectronic medicines compendium (eMC), UK

• Common: bradycardia, cold extremities, gastrointestinal disturbances (including nausea), fatigue; related to chlortalidone: hyperuricaemia, hyponatraemia, hypokalaemia, impaired glucose tolerance. Uncommon: sleep disturbances, elevated transaminases. Rare: purpura, thrombocytopenia, leucopenia, mood changes, dizziness, headache, paraesthesia, visual disturbances, heart failure deterioration, heart block, postural hypotension, bronchospasm in asthmatics, dry mouth, hepatic toxicity, pancreatitis, alopecia, psoriasiform reactions, rash, impotence. Not known: depression, choroidal effusion, constipation, hypersensitivity (angioedema, urticaria), lupus-like syndrome.International label, equivalent formulation · electronic medicines compendium (eMC), UK

• Hypersensitivity to the active substances (or to sulphonamide-derived medicines) or any excipient; bradycardia; cardiogenic shock; hypotension; metabolic acidosis; severe peripheral arterial circulatory disturbances; second- or third-degree heart block; sick sinus syndrome; untreated phaeochromocytoma; severe renal failure; uncontrolled heart failure; pregnancy and lactation.International label, equivalent formulation · electronic medicines compendium (eMC), UK

• May be used in controlled heart failure with caution (poor cardiac reserve); may increase angina attacks in Prinzmetal's angina; may aggravate less severe peripheral arterial disease; caution in first-degree heart block; reduce dose if symptomatic bradycardia (pulse <50-55 bpm at rest).International label, equivalent formulation · electronic medicines compendium (eMC), UK
• May mask symptoms of hypoglycaemia (particularly tachycardia) and signs of thyrotoxicosis; with sulfonylureas the risk of severe hypoglycaemia may increase.International label, equivalent formulation · electronic medicines compendium (eMC), UK
• Avoid in reversible obstructive airways disease unless there are compelling reasons (use with caution; bronchospasm reversible with bronchodilators). May cause more severe reactions to allergens with reduced response to adrenaline; hypersensitivity including angioedema and urticaria. In phaeochromocytoma give with an alpha-blocker.International label, equivalent formulation · electronic medicines compendium (eMC), UK

• Verapamil, diltiazemExaggerated negative inotropic effects with possible severe hypotension, bradycardia and cardiac failure; no IV administration of either within 48 hours of stopping the other.electronic medicines compendium (eMC), UK
• Class I antiarrhythmics (e.g. disopyramide), amiodarone, digitalis glycosidesPotentiated atrial-conduction time / AV conduction time and negative inotropic effect.electronic medicines compendium (eMC), UK
• ClonidineExacerbated rebound hypertension on clonidine withdrawal; withdraw the beta-blocker several days before clonidine.electronic medicines compendium (eMC), UK

• Must not be given during pregnancy.International label, equivalent formulation · electronic medicines compendium (eMC), UK
• Must not be given during lactation.International label, equivalent formulation · electronic medicines compendium (eMC), UK

• Atenolol: Beta1-selective beta-adrenergic receptor blocker without membrane-stabilizing or intrinsic sympathomimetic activity; selectivity is not absolute and higher doses also inhibit beta2 receptors (US label).
• Chlortalidone (chlorthalidone): Monosulfonamyl diuretic that increases sodium and chloride excretion, with some potassium loss; the blood-pressure-lowering mechanism is not fully known but may relate to excretion and redistribution of body sodium (UK SmPC).