سعر اميكاسين ايبيكو 100مجم/2مل حقن فيال عضل/وريد 2024

Amikacin (as sulfate) 100 mg/2 mL solution for intramuscular or intravenous injection, 1 vial (2 mL) (EIPICO); an aminoglycoside antibiotic for serious Gram-negative infections.

• Ototoxicity (hearing loss, loss of balance), neuromuscular blockade (acute muscular paralysis, apnoea) and nephrotoxicity (raised creatinine, albuminuria, casts, azotaemia, oliguria; acute renal failure postmarketing). Rarely: rash, drug fever, headache, paraesthesia, tremor, nausea and vomiting, eosinophilia, arthralgia, anaemia, hypotension, hypomagnesaemia.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• History of hypersensitivity to amikacin; hypersensitivity or serious toxic reactions to other aminoglycosides may contraindicate use because of cross-sensitivity.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: potential ototoxicity (vestibular and permanent bilateral auditory) and nephrotoxicity; risk is greater with renal impairment, higher doses or prolonged therapy; keep patients under close clinical observation.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: neuromuscular blockade and respiratory paralysis, especially with anaesthetics, neuromuscular blocking agents or massive citrate-anticoagulated blood transfusions.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: avoid concurrent or sequential use of other neurotoxic or nephrotoxic drugs (e.g. bacitracin, cisplatin, amphotericin B, polymyxin B, colistin, vancomycin, other aminoglycosides) and potent diuretics (ethacrynic acid, furosemide).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Aminoglycosides can cause fetal harm (irreversible congenital deafness reported with streptomycin).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• The US product contains sodium metabisulfite, which may cause allergic-type reactions in susceptible people (Egyptian excipients not verified).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhoea may occur.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Increased ototoxicity risk in carriers of mitochondrial MT-RNR1 variants (particularly m.1555A>G), even with serum levels in range.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Use with caution in myasthenia gravis or parkinsonism; keep patients well hydrated; use with caution in premature and neonatal infants.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Potent diuretics (ethacrynic acid, furosemide)Avoid concurrent use: diuretics may cause ototoxicity and, given IV, may enhance aminoglycoside toxicity.DailyMed (U.S. National Library of Medicine)
• Other neurotoxic/nephrotoxic drugs (e.g. cisplatin, amphotericin B, vancomycin, polymyxins, other aminoglycosides, cephalosporins)Avoid concurrent or sequential use because of additive nephrotoxicity, ototoxicity and neurotoxicity.DailyMed (U.S. National Library of Medicine)
• Anaesthetics and neuromuscular blocking agentsRisk of neuromuscular blockade and respiratory paralysis.DailyMed (U.S. National Library of Medicine)
• Beta-lactam antibiotics (penicillins, cephalosporins)Do not mix in vitro (mutual inactivation); inactivation is clinically significant mainly in severe renal impairment.DailyMed (U.S. National Library of Medicine)

• It is not known whether amikacin is excreted in human milk; decide whether to discontinue nursing or the drug, considering its importance to the mother.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Monitor renal and eighth cranial nerve function (audiometry where feasible), urine and serum amikacin concentrations (avoid peaks >35 mcg/mL and troughs >10 mcg/mL); reassess renal function periodically during therapy.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Amikacin: Binds to the bacterial (prokaryotic) ribosome and inhibits protein synthesis; bactericidal in vitro against Gram-positive and Gram-negative bacteria (US label).