سعر اوجمنتين ديو 228مجم/5مل زجاجة معلق 70 مل 2025

Augmentin Duo 228.5 mg/5 ml (amoxicillin 200 mg + clavulanic acid 28.5 mg per 5 ml) powder for oral suspension, 70 ml; penicillin with beta-lactamase inhibitor.

• Upper respiratory tract infections (including ENT), e.g. recurrent tonsillitis, sinusitis, otitis mediaPopulation: Children (twice-daily oral dosing)GSK India (india-pharma.gsk.com)
• Lower respiratory tract infections, e.g. acute exacerbation of chronic bronchitis, lobar and bronchopneumoniaPopulation: Children (twice-daily oral dosing)GSK India (india-pharma.gsk.com)
• Urinary tract infections, e.g. cystitis, urethritis, pyelonephritisPopulation: Children (twice-daily oral dosing)GSK India (india-pharma.gsk.com)

• Children: diarrhoea, nausea and vomiting are common; mucocutaneous candidiasis is common. Uncommon: dizziness, headache, indigestion, rash, pruritus, urticaria, moderate rise in AST/ALT. Rare/very rare: erythema multiforme, blood dyscrasias, severe skin reactions, hepatitis, cholestatic jaundice, interstitial nephritis, crystalluria, superficial tooth discolouration.International label, same product · GSK India (india-pharma.gsk.com)
• Most frequently reported adverse reactions: diarrhea/loose stools (9%), nausea (3%), skin rashes and urticaria (3%), vomiting (1%) and vaginitis (1%); incidence, particularly of diarrhea, increases with higher doses.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Postmarketing: indigestion, gastritis, stomatitis, glossitis, DIES, black hairy tongue, mucocutaneous candidiasis, hemorrhagic/pseudomembranous colitis; anaphylaxis, angioedema, serum sickness-like reactions, hypersensitivity vasculitis; severe skin reactions; hepatitis and cholestatic jaundice; interstitial nephritis, crystalluria; blood dyscrasias; CNS effects including convulsions; tooth discoloration.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• History of hypersensitivity to beta-lactams, e.g. penicillins and cephalosporins.International label, same product · GSK India (india-pharma.gsk.com)
• Previous history of amoxicillin-clavulanate-associated jaundice/hepatic dysfunction.International label, same product · GSK India (india-pharma.gsk.com)
• History of a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to amoxicillin, clavulanate or other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Serious and occasionally fatal hypersensitivity reactions, Kounis syndrome, drug-induced enterocolitis syndrome (mainly in children) and haemophagocytic lymphohistiocytosis have been reported; discontinue and treat appropriately.International label, same product · GSK India (india-pharma.gsk.com)
• Avoid if infectious mononucleosis is suspected; pseudomembranous colitis and overgrowth of non-susceptible organisms may occur; INR may be prolonged with oral anticoagulants; use with caution in hepatic dysfunction (cholestatic jaundice may appear up to 6 weeks after treatment).International label, same product · GSK India (india-pharma.gsk.com)
• Maintain adequate fluid intake at high doses (crystalluria). Contains aspartame (phenylalanine source) - caution in phenylketonuria.International label, same product · GSK India (india-pharma.gsk.com)

• ProbenecidNot recommended; increases and prolongs amoxicillin (not clavulanic acid) blood levels.GSK India (india-pharma.gsk.com)
• AllopurinolMay increase the likelihood of allergic skin reactions with amoxicillin.GSK India (india-pharma.gsk.com)
• Combined oral contraceptivesReduced efficacy possible through effects on gut flora.GSK India (india-pharma.gsk.com)

• Animal studies showed no teratogenic effects; prophylactic use in women with preterm premature rupture of membranes may be associated with necrotising enterocolitis in neonates; avoid in pregnancy unless considered essential by the physician.International label, same product · GSK India (india-pharma.gsk.com)
• Reproduction studies in pregnant rats and mice at oral doses up to 1200 mg/kg/day revealed no evidence of fetal harm; there are no adequate and well-controlled studies in pregnant women; use during pregnancy only if clearly needed. Oral ampicillin-class antibacterials are poorly absorbed during labor.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• May be given during lactation; apart from the risk of sensitisation from trace amounts in breast milk, no detrimental effects for the breastfed infant are known.International label, same product · GSK India (india-pharma.gsk.com)

• Amoxicillin: Bactericidal penicillin that inhibits bacterial cell-wall biosynthesis; susceptible to degradation by beta-lactamases, which clavulanic acid inhibits.
• Clavulanic acid: Beta-lactam structurally related to the penicillins that inactivates many beta-lactamase enzymes, protecting amoxicillin from degradation and extending its antibacterial spectrum.