سعر لارينكلاف 400/57 مجم باودر لعمل معلق 70 مل 2022

Amoxicillin 400 mg + clavulanic acid 57 mg powder for oral suspension (70 ml after reconstitution) by Misr > Al Rowad Pharmaceutical Industrial Co. (Egypt); penicillin with beta-lactamase inhibitor.

• Acute bacterial sinusitis (adequately diagnosed)Population: Adults and children (this suspension is intended for children <40 kg)Electronic Medicines Compendium (emc, medicines.org.uk)
• Acute otitis mediaPopulation: Adults and children (this suspension is intended for children <40 kg)Electronic Medicines Compendium (emc, medicines.org.uk)
• Acute exacerbations of chronic bronchitis (adequately diagnosed)Population: Adults and children (this suspension is intended for children <40 kg)Electronic Medicines Compendium (emc, medicines.org.uk)

• Most commonly reported adverse reactions are diarrhoea, nausea and vomiting; mucocutaneous candidosis is common.International label, same formulation · Electronic Medicines Compendium (emc, medicines.org.uk)

• Hypersensitivity to the active substances, to any of the penicillins or to any of the excipients.International label, same formulation · Electronic Medicines Compendium (emc, medicines.org.uk)
• History of a severe immediate hypersensitivity reaction (e.g. anaphylaxis) to another beta-lactam agent (e.g. a cephalosporin, carbapenem or monobactam).International label, same formulation · Electronic Medicines Compendium (emc, medicines.org.uk)
• History of jaundice/hepatic impairment due to amoxicillin/clavulanic acid.International label, same formulation · Electronic Medicines Compendium (emc, medicines.org.uk)

• Enquire about previous hypersensitivity to penicillins, cephalosporins or other beta-lactams. Serious and occasionally fatal hypersensitivity reactions (including anaphylactoid and severe cutaneous adverse reactions) have been reported and may progress to Kounis syndrome; they are more likely with a history of penicillin hypersensitivity and in atopic individuals. If an allergic reaction occurs, stop therapy and institute an appropriate alternative.International label, same formulation · Electronic Medicines Compendium (emc, medicines.org.uk)
• Drug-induced enterocolitis syndrome (DIES), with protracted vomiting 1-4 hours after dosing, has been reported mainly in children; severe cases including shock have occurred.International label, same formulation · Electronic Medicines Compendium (emc, medicines.org.uk)
• Haemophagocytic lymphohistiocytosis (HLH)/macrophage activation syndrome (MAS), which can be life-threatening, has been reported; evaluate promptly patients with fever, rash, hepatosplenomegaly, lymphadenopathy or cytopenias and stop treatment unless another cause is established.International label, same formulation · Electronic Medicines Compendium (emc, medicines.org.uk)

• Oral anticoagulants (warfarin, acenocoumarol)Cases of increased INR reported; monitor prothrombin time/INR when amoxicillin is added or withdrawn and adjust the anticoagulant dose if necessary.Electronic Medicines Compendium (emc, medicines.org.uk)
• MethotrexatePenicillins may reduce methotrexate excretion, potentially increasing its toxicity.Electronic Medicines Compendium (emc, medicines.org.uk)
• ProbenecidNot recommended: decreases renal tubular secretion of amoxicillin, increasing and prolonging amoxicillin (not clavulanic acid) blood levels.Electronic Medicines Compendium (emc, medicines.org.uk)

• Animal studies show no harmful effects and limited human data do not indicate an increased risk of congenital malformations. In one study in women with preterm premature rupture of the foetal membranes, prophylactic amoxicillin/clavulanic acid may have been associated with an increased risk of necrotising enterocolitis in neonates. Avoid during pregnancy unless considered essential by the physician.International label, same formulation · Electronic Medicines Compendium (emc, medicines.org.uk)
• US label (older format, historical FDA Pregnancy Category B): no evidence of fetal harm in rat and mouse reproduction studies, but no adequate and well-controlled studies in pregnant women; use during pregnancy only if clearly needed.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Both substances are excreted into breast milk; diarrhoea and fungal infection of the mucous membranes are possible in the breast-fed infant (breast-feeding might have to be discontinued) and sensitisation should be considered. Use during breast-feeding only after benefit/risk assessment by the physician.International label, same formulation · Electronic Medicines Compendium (emc, medicines.org.uk)

• Amoxicillin: Bactericidal beta-lactam that inhibits bacterial cell-wall biosynthesis during active multiplication; inactivated by beta-lactamases (US label, section 12.4).
• Clavulanic acid: Beta-lactam that inactivates some beta-lactamases, protecting amoxicillin from degradation.