سعر اوازي 600مجم 10 اقراص 2024

Linezolid 600 mg film-coated tablets, pack of 10 (1 strip); oxazolidinone antibacterial (HP Pharma, Egypt).

• Nosocomial pneumonia caused by Staphylococcus aureus (MSSA/MRSA) or Streptococcus pneumoniaePopulation: Adults and childrenDailyMed (U.S. National Library of Medicine)
• Community-acquired pneumonia caused by Streptococcus pneumoniae (including bacteraemia) or methicillin-susceptible Staphylococcus aureusPopulation: Adults and childrenDailyMed (U.S. National Library of Medicine)
• Complicated skin and skin structure infections, including diabetic foot infections without osteomyelitisPopulation: Adults and childrenDailyMed (U.S. National Library of Medicine)

• Most frequent adverse reactions in adult comparator-controlled trials: headache, diarrhoea, nausea, vomiting, dizziness, rash, anaemia, taste alteration and abnormal liver function tests.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Post-marketing: anaphylaxis, angioedema, severe cutaneous reactions (SJS/TEN), myelosuppression, sideroblastic anaemia, peripheral and optic neuropathy, lactic acidosis, convulsions and rhabdomyolysis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to linezolid or any product component.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Patients taking any monoamine oxidase A or B inhibitor (e.g. phenelzine, isocarboxazid) or within two weeks of taking one.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Myelosuppression (anaemia, leukopenia, pancytopenia, thrombocytopenia) may occur; monitor complete blood counts weekly, especially with therapy longer than two weeks, pre-existing myelosuppression or severe renal/moderate-severe hepatic impairment.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Peripheral and optic neuropathy, mainly with treatment beyond 28 days; prompt ophthalmic evaluation if visual symptoms occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serotonin syndrome (including fatal cases) with concomitant serotonergic agents such as SSRIs, SNRIs, tricyclics, triptans and opioids.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Monoamine oxidase inhibitorsLinezolid is a reversible nonselective MAO inhibitor; concomitant use with MAO-A/B inhibitors or within 2 weeks is contraindicated.DailyMed (U.S. National Library of Medicine)
• Serotonergic agents (SSRIs, SNRIs, tricyclic antidepressants, triptans, buspirone, opioids incl. meperidine)Risk of serotonin syndrome; monitor closely.DailyMed (U.S. National Library of Medicine)
• Sympathomimetics (e.g. pseudoephedrine, phenylpropanolamine), vasopressors, dopaminergic agentsEnhanced pressor response; reduce and titrate initial doses of adrenergic agents and monitor blood pressure.DailyMed (U.S. National Library of Medicine)

• Available data from published and post-marketing case reports have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes; embryo-fetal lethality occurred in mice at about 6.5 times human exposure.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Linezolid is present in breast milk (infant dose about 6-9% of the therapeutic infant dose); monitor the breastfed infant for diarrhoea and vomiting.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Linezolid: Binds the 23S rRNA of the bacterial 50S ribosomal subunit and prevents formation of a functional 70S initiation complex, inhibiting bacterial protein synthesis; also a reversible, nonselective monoamine oxidase inhibitor.