سعر ازيلاست بلاس 125/50 مكجم سبراي للانف 25 مل 2024

Azelast Plus nasal spray delivering azelastine 125 mcg (as hydrochloride) and fluticasone propionate 50 mcg per actuation, an antihistamine/corticosteroid combination marketed in Egypt by Hikma Pharma; 25 ml bottle.

• Relief of symptoms of moderate to severe seasonal and perennial allergic rhinitis when monotherapy with an intranasal antihistamine or glucocorticoid is not considered sufficientPopulation: Adults and adolescents 12 years and olderelectronic medicines compendium (eMC)
• Relief of symptoms of seasonal allergic rhinitisPopulation: Adults and children 6 years and olderDailyMed (U.S. National Library of Medicine)

• Very common: epistaxis. Common: headache, dysgeusia (unpleasant taste), unpleasant smell. Uncommon: nasal discomfort, sneezing, nasal dryness, cough, dry throat, throat irritation. Rare: dry mouth. Very rare: hypersensitivity incl. anaphylaxis, angioedema, bronchospasm; dizziness, somnolence; glaucoma, raised intraocular pressure, cataract; nasal septal perforation; nausea; rash, pruritus, urticaria; fatigue. Not known: blurred vision, nasal ulcers.International label, same formulation · electronic medicines compendium (eMC)

• Hypersensitivity to the active substances or any excipient.International label, same formulation · electronic medicines compendium (eMC)

• Avoid co-administration with ritonavir or other potent CYP3A4 inhibitors (including cobicistat) unless benefit outweighs risk of systemic corticosteroid effects (Cushing's syndrome, adrenal suppression).International label, same formulation · electronic medicines compendium (eMC)
• Systemic corticosteroid effects possible at high doses or prolonged use (adrenal suppression, growth retardation in children/adolescents - monitor growth, cataract, glaucoma, psychological effects); visual disturbance should prompt ophthalmology referral.International label, same formulation · electronic medicines compendium (eMC)
• Caution in tuberculosis, untreated infections, or recent nasal/oral surgery or injury; care when transferring from systemic steroids if adrenal function may be impaired; contains benzalkonium chloride (long-term use may cause nasal mucosal oedema).International label, same formulation · electronic medicines compendium (eMC)

• Ritonavir, cobicistat and other potent CYP3A4 inhibitors (e.g. ketoconazole)Greatly increased fluticasone propionate exposure with systemic corticosteroid effects; avoid unless benefit outweighs risk, then monitor.electronic medicines compendium (eMC)
• Sedatives, CNS depressants, alcoholSedative effect of azelastine may be enhanced.electronic medicines compendium (eMC)

• No or limited data in pregnant women; use in pregnancy only if the potential benefit justifies the potential risk to the foetus.International label, same formulation · electronic medicines compendium (eMC)
• Limited postmarketing data in pregnant women have not identified drug-associated risks of miscarriage, birth defects or other adverse maternal or fetal outcomes.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Unknown whether excreted in breast milk; use during lactation only if the potential benefit justifies the potential risk to the infant.International label, same formulation · electronic medicines compendium (eMC)

• Azelastine: H1-receptor antagonist; the major metabolite desmethylazelastine is also H1-antagonist active.
• Fluticasone propionate: Potent glucocorticoid-receptor agonist with anti-inflammatory activity; precise mechanism in allergic rhinitis unknown.