سعر بيزبون 2 قرص 2022

Film-coated tablets combining the bisphosphonate alendronic acid with cholecalciferol (vitamin D3), reported by Altibbi as 70 mg + 2800 IU taken once weekly; October Pharma, Egypt; 2 tablets per pack. Listed for postmenopausal osteoporosis.

• Treatment of osteoporosis in postmenopausal women (increases bone mass and reduces hip and vertebral fractures)Population: Postmenopausal womenDailyMed (U.S. National Library of Medicine)
• Treatment to increase bone mass in men with osteoporosisPopulation: Adult menDailyMed (U.S. National Library of Medicine)

• Most common (at least 3%): abdominal pain, acid regurgitation, constipation, diarrhoea, dyspepsia, musculoskeletal pain and nausea.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Abnormalities of the oesophagus that delay emptying (e.g., stricture or achalasia); inability to stand or sit upright for at least 30 minutes; hypocalcaemia; hypersensitivity to any component.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Upper gastrointestinal adverse reactions (dysphagia, oesophagitis, oesophageal ulcers/erosions); stop and seek care if dysphagia, odynophagia, retrosternal pain or new/worsening heartburn occurs; use with caution in active upper GI disease.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Correct hypocalcaemia and other disturbances of mineral metabolism before starting; ensure adequate calcium and vitamin D intake. The product alone should not be used to treat vitamin D deficiency.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Severe, occasionally incapacitating bone, joint and/or muscle pain; osteonecrosis of the jaw; atypical femoral fractures (evaluate new thigh or groin pain).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Calcium supplements, antacids and oral medicines containing multivalent cationsInterfere with alendronate absorption; wait at least 30 minutes after the dose before taking any other oral medicine.DailyMed (U.S. National Library of Medicine)
• Aspirin and NSAIDsIncreased incidence of upper GI adverse events (aspirin with alendronate >10 mg/day); NSAIDs are GI irritants, use with caution.DailyMed (U.S. National Library of Medicine)
• Anticonvulsants, cimetidine and thiazidesMay increase the catabolism of vitamin D.DailyMed (U.S. National Library of Medicine)

• Available human data are insufficient to inform a drug-associated risk; discontinue when pregnancy is recognised. In rats, alendronate reduced post-implantation survival and fetal ossification.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Cholecalciferol and some active metabolites pass into breast milk; it is not known whether alendronate is present in human milk; weigh benefits of breastfeeding against the mother's need for the drug.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Alendronic acid: Binds to bone hydroxyapatite and specifically inhibits osteoclast-mediated bone resorption (US label, section 12.1).
• Cholecalciferol (vitamin D3): Converted in liver and kidney to calcitriol, which increases intestinal absorption of calcium and phosphate (US label, section 12.1).