سعر بيولجام 50/30 مجم 8 أقراص مغلفة 2022

Biolegam (also styled Bio Legam / بيولجام) 50/30 mg film-coated tablets by Biomed: sildenafil 50 mg + dapoxetine 30 mg, pack of 8. Egyptian directories list it for erectile dysfunction and delayed ejaculation (tonic for men/delay). No official Egyptian package insert was opened; clinical content below is ingredient-level from UK sildenafil SmPC and EU/SE Priligy (dapoxetine) SmPC. Note: Priligy SmPC advises against use with PDE5 inhibitors due to orthostatic risk — relevant for this combination.

• Erectile dysfunction and premature ejaculation in men (as stated by Egyptian pharmacy/directory listings for Biolegam; no official Egyptian SmPC opened).Population: Adult men (per pharmacy listings; age limits not verified on an official Egyptian label)
• Sildenafil monotherapy indication (UK SmPC): adult men with erectile dysfunction; sexual stimulation required.Population: Adult menMHRA eMC / Krka
• Dapoxetine monotherapy indication (Priligy SmPC): premature ejaculation in adult men 18–64 who meet defined PE criteria; on-demand only.Population: Adult men aged 18 to 64 years meeting PE diagnostic criteriaSwedish MPA / EU-DCP Priligy SmPC

• Sildenafil common ARs: headache, flushing, dyspepsia, nasal congestion, dizziness, nausea, visual disturbances (including cyanopsia), hot flush.General active-ingredient information · MHRA eMC / Krka
• Dapoxetine common ARs (dose-related): nausea, dizziness, headache, diarrhoea, insomnia, fatigue; syncope and orthostatic hypotension reported.General active-ingredient information · Swedish MPA / EU-DCP Priligy SmPC

• Sildenafil: contraindicated with nitrates/NO donors (any form), riociguat; in men for whom sexual activity is inadvisable (severe CVD); NAION with prior vision loss in one eye; severe hepatic impairment, hypotension <90/50 mmHg, recent stroke/MI, hereditary degenerative retinal disorders (e.g. retinitis pigmentosa).General active-ingredient information · MHRA eMC / Krka
• Dapoxetine (Priligy): contraindicated with significant cardiac disease (HF NYHA II–IV, conduction blocks, significant IHD/valvular disease, syncope history), mania/severe depression, MAOIs, thioridazine, other serotonergic agents, potent CYP3A4 inhibitors, moderate/severe hepatic impairment.General active-ingredient information · Swedish MPA / EU-DCP Priligy SmPC

• CRITICAL COMBINATION CAUTION: Priligy SmPC states dapoxetine should not be used in men with erectile dysfunction who are using PDE5 inhibitors, due to possible reduced orthostatic tolerance; efficacy/safety of dapoxetine + PDE5 inhibitors together for PE+ED were not established. Biolegam is a fixed sildenafil+dapoxetine combination — pharmacist/physician review of this conflict is required.General active-ingredient information · Swedish MPA / EU-DCP Priligy SmPC
• Sildenafil: assess CV status before ED treatment; risk of priapism; sudden vision/hearing loss — stop and seek care; caution with alpha-blockers (start 25 mg); avoid ritonavir co-administration.General active-ingredient information · MHRA eMC / Krka
• Dapoxetine: orthostatic hypotension and syncope risk (counsel on hydration and prodromal symptoms); avoid alcohol; not for continuous daily use; suicide risk considerations with SSRIs in young patients.General active-ingredient information · Swedish MPA / EU-DCP Priligy SmPC

• Nitrates / nitric oxide donors (e.g. GTN, isosorbide, amyl nitrite, nicorandil)MajorSildenafil potentiates hypotensive effects of nitrates via NO/cGMP pathway. Absolute contraindication with sildenafil component.MHRA eMC / Krka
• PDE5 inhibitors used together with dapoxetine (including sildenafil in fixed combination)MajorPossible reduced orthostatic tolerance; Priligy SmPC advises against use of dapoxetine with PDE5 inhibitors. PK of dapoxetine only slightly changed by sildenafil 100 mg. Priligy: do not use with PDE5 inhibitors. Biolegam is a fixed combo — treat as high-priority pharmacist review item.Swedish MPA / EU-DCP Priligy SmPC
• Potent CYP3A4 inhibitors (ketoconazole, ritonavir, etc.)MajorIncrease exposure of both sildenafil and dapoxetine. Contraindicated with dapoxetine (Priligy); sildenafil — ritonavir not advised / max 25 mg in 48 h; start sildenafil 25 mg with other CYP3A4 inhibitors.MHRA eMC / Krka, Swedish MPA / EU-DCP Priligy SmPC

• Neither sildenafil nor dapoxetine is indicated for use by women. No adequate human pregnancy/lactation data for therapeutic ED/PE use.General active-ingredient information · MHRA eMC / Krka, Swedish MPA / EU-DCP Priligy SmPC
• Unknown whether dapoxetine or metabolites are excreted in human milk (Priligy). Sildenafil not indicated in women.General active-ingredient information · Swedish MPA / EU-DCP Priligy SmPC

• Sildenafil (as citrate per Seif Pharmacies listing): Inhibits PDE5, the enzyme that degrades cGMP in the corpus cavernosum, enhancing the nitric oxide effect during sexual stimulation (smooth-muscle relaxation and inflow of blood).
• Dapoxetine (as HCl per Seif Pharmacies listing): Potent SSRI; inhibition of neuronal serotonin reuptake and potentiation of serotonin action at pre- and post-synaptic receptors is presumed to delay the ejaculatory reflex (supraspinal control) (EU-DCP SmPC, Sweden).