سعر اندوداريسين 7.5مجم 20 قرص 2025

Extended-release film-coated tablets containing darifenacin 7.5 mg (Al Andalous Pharmaceutical Industries); 20 tablets per pack. Listed for urinary incontinence and bladder control problems.

• Overactive bladder with urge urinary incontinence, urgency and frequencyPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency in adults with overactive bladderPopulation: AdultsAl Andalous Pharmaceutical Industries (manufacturer website)

• Most common adverse reactions: dry mouth and constipation.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma (or patients at risk of these conditions).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Use with caution in clinically significant bladder outflow obstruction (urinary retention risk) and GI obstructive disorders or decreased GI motility (severe constipation, ulcerative colitis, myasthenia gravis).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Angioedema of the face, lips, tongue or larynx has been reported, sometimes after the first dose; discontinue and treat promptly if it occurs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Controlled narrow-angle glaucoma: use only if benefits outweigh risks; anticholinergic CNS effects (e.g., dizziness, somnolence) may occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Potent CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir, nelfinavir, clarithromycin, nefazodone)Increase darifenacin exposure; daily dose should not exceed 7.5 mg.DailyMed (U.S. National Library of Medicine)
• CYP2D6 substrates with a narrow therapeutic window (e.g., flecainide, thioridazine, tricyclic antidepressants)Darifenacin may increase their levels; use with caution.DailyMed (U.S. National Library of Medicine)
• Other anticholinergic agentsMay increase frequency/severity of dry mouth, constipation, blurred vision and other anticholinergic effects.DailyMed (U.S. National Library of Medicine)

• No available human data; not teratogenic in rats and rabbits at exposures well above the maximum human dose.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No human milk data; present in rat milk, so likely present in human milk - weigh benefits of breastfeeding against the need for treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Darifenacin (salt form not stated): Competitive muscarinic receptor antagonist with greater affinity for the M3 receptor, which mediates contraction of bladder smooth muscle.