سعر بيوجليتا بلس 15/500 مجم 30 قرص مغلف 2024

Film-coated tablets containing pioglitazone 15 mg and metformin 500 mg; Arab Caps > Andalous Pharma; 30 tablets.

• Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (US Actoplus Met)DailyMed / Takeda

• Most common (>5%): upper respiratory tract infection, edema, diarrhea, headache, weight gain.International label, equivalent formulation · DailyMed / Takeda

• NYHA Class III or IV heart failure at initiation; severe renal impairment (eGFR <30 mL/min); serious hypersensitivity to pioglitazone, metformin, or excipients; acute or chronic metabolic acidosis including diabetic ketoacidosis.General active-ingredient information · DailyMed / Takeda

• BOXED WARNING — Congestive heart failure: thiazolidinediones including pioglitazone can cause or exacerbate CHF. Monitor for weight gain, dyspnea, edema; not recommended in symptomatic heart failure.General active-ingredient information · DailyMed / Takeda
• BOXED WARNING — Metformin-associated lactic acidosis: rare but serious; risk factors include renal impairment, hypoxia, excessive alcohol, hepatic impairment, age ≥65, iodinated contrast. Discontinue if suspected and hospitalize.General active-ingredient information · DailyMed / Takeda
• May increase risk of bladder cancer — do not use with active bladder cancer; caution with prior history. Increased fracture risk in females. Monitor for macular edema and vitamin B12 deficiency.General active-ingredient information · DailyMed / Takeda

• Strong CYP2C8 inhibitors (e.g. gemfibrozil)MajorLimit combination dose (US: max 15 mg/850 mg daily with strong CYP2C8 inhibitors).DailyMed / Takeda
• AlcoholMajorWarn against excessive alcohol intake (potentiates metformin lactic acidosis risk).DailyMed / Takeda
• Insulin or insulin secretagoguesModerateMay increase hypoglycemia risk; consider dose reduction of secretagogue/insulin.DailyMed / Takeda

• Limited data; poorly controlled diabetes in pregnancy carries maternal/fetal risks. Discuss unintended pregnancy risk (ovulation may resume in some anovulatory women).General active-ingredient information · DailyMed / Takeda

• Pioglitazone: Thiazolidinedione that depends on the presence of insulin; decreases insulin resistance in the periphery and liver via PPAR-gamma agonism (US Duetact label).
• Metformin: Decreases hepatic glucose production, decreases intestinal glucose absorption and improves insulin sensitivity by increasing peripheral glucose uptake and utilization; insulin secretion remains unchanged (US label).