سعر كاربابكس سي ار Carbapex CR‏ 400مجم 30 قرص 2026

Carbapex CR 400 mg controlled-release tablets (carbamazepine, 30 tablets) by Multi-Apex, an antiepileptic.

• Contraindicated with a history of bone marrow depression, hypersensitivity to carbamazepine or to tricyclic compounds, with nefazodone, and with MAO inhibitors (stop them at least 14 days before).International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Serious and sometimes fatal dermatologic reactions (toxic epidermal necrolysis, Stevens-Johnson syndrome) have been reported; risk is strongly associated with the HLA-B*1502 allele, found mainly in patients of Asian ancestry, who should be screened before starting.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Aplastic anemia and agranulocytosis have been reported; obtain baseline haematological testing and consider discontinuation if significant bone marrow depression develops.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Anaphylaxis and angioedema (including laryngeal oedema, which can be fatal) have been reported after first or later doses.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• CYP3A4 inhibitors and inducers; drugs metabolised by CYP3A4 (e.g. hormonal contraceptives)Carbamazepine is a CYP3A4 substrate and inducer: inhibitors raise its levels, inducers lower them, and it can lower levels of co-administered CYP3A4 substrates including hormonal contraceptives.DailyMed (US National Library of Medicine)

• Carbamazepine can cause fetal harm; adverse effects on reproduction were seen in rats and neonatal seizures/respiratory depression have been reported; weigh benefit against risk.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Carbamazepine: Prolongs the inactivated state of voltage-gated neuronal sodium channels, reducing high-frequency neuronal firing.