سعر اوكساتريليبازين 600مجم 10 اقراص 2022

Oxatrilepazine 600 mg 10 film-coated tablets: oxcarbazepine 600 mg film-coated tablet by Medizen Pharmaceutical Industries > Mira International; pack: 10 film-coated tablets. Antiepileptic.

• Monotherapy or adjunctive therapy of partial-onset seizures in adults.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Monotherapy of partial-onset seizures in children 4-16 years; adjunctive therapy in children 2-16 years.Population: Paediatric patientsDailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to oxcarbazepine or any component, or to eslicarbazepine acetate.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Clinically significant hyponatraemia (sodium < 125 mmol/L) can develop, usually in the first 3 months; monitor serum sodium.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Cross-hypersensitivity with carbamazepine; serious dermatological reactions (SJS/TEN) - HLA-B*1502 carriers may be at increased risk; suicidal behaviour and ideation; cognitive/neuropsychiatric effects; DRESS.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hormonal contraceptivesOxcarbazepine may reduce the effectiveness of hormonal contraceptives; additional non-hormonal contraception is advised.DailyMed (U.S. National Library of Medicine)
• PhenytoinPhenytoin levels may increase at oxcarbazepine doses > 1200 mg/day; monitor and reduce phenytoin if needed.DailyMed (U.S. National Library of Medicine)
• Strong CYP3A4/UGT inducers (rifampin, carbamazepine, phenytoin, phenobarbital)Decrease MHD levels; dose adjustment may be needed.DailyMed (U.S. National Library of Medicine)

• Structurally related to carbamazepine (a human teratogen); available human registry/literature data are summarised in the US label; enrol exposed women in the NAAED Pregnancy Registry.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Oxcarbazepine and MHD are present in human milk; effects on the infant are unknown - weigh benefits against risks.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Oxcarbazepine: Acts mainly through its 10-monohydroxy metabolite (MHD); oxcarbazepine and MHD block voltage-sensitive sodium channels, stabilising hyperexcited neural membranes and inhibiting repetitive neuronal firing (US Trileptal label 12.1).