سعر تيجرابين 400مجم اكس ار 10 اقراص 2022

Carbamazepine 400 mg extended-release tablets, 10 tablets, by Sigma (Egypt); antiepileptic (carboxamide).

• Epilepsy: partial seizures with complex symptomatology, generalized tonic-clonic seizures and mixed seizure patterns (not effective for absence seizures).Population: Adults and childrenDailyMed (U.S. National Library of Medicine)
• Pain of true trigeminal neuralgia (not a simple analgesic).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most frequent, especially early in therapy: dizziness, drowsiness, unsteadiness, nausea and vomiting; most severe reactions involve the hemopoietic system, skin, liver and cardiovascular system.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• History of bone marrow depression; hypersensitivity to carbamazepine or known sensitivity to tricyclic compounds; use with MAO inhibitors not recommended (discontinue MAOIs at least 14 days before); coadministration with nefazodone is contraindicated.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: serious and sometimes fatal dermatologic reactions (TEN/SJS), strongly associated with HLA-B*1502; screen patients with ancestry in genetically at-risk (Asian) populations before starting and avoid if positive unless benefit clearly outweighs risk.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: aplastic anemia and agranulocytosis; obtain pretreatment hematologic testing and consider discontinuation if significant bone marrow depression develops.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Antiepileptic drugs increase the risk of suicidal thoughts and behavior; other warnings include hypersensitivity/DRESS, angioedema, hepatic damage, hyponatremia, and dizziness/drowsiness affecting driving; avoid abrupt discontinuation.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• CYP3A4 inhibitors and inducersCarbamazepine is metabolized by CYP3A4; inhibitors raise and inducers lower its plasma levels.DailyMed (U.S. National Library of Medicine)
• Hormonal contraceptivesCarbamazepine may make oral and other hormonal contraceptives less effective; breakthrough bleeding and unintended pregnancies reported; consider alternative or back-up contraception.DailyMed (U.S. National Library of Medicine)
• Direct oral anticoagulants (rivaroxaban, apixaban, dabigatran, edoxaban)Expected decrease in anticoagulant concentrations; coadministration should generally be avoided.DailyMed (U.S. National Library of Medicine)

• Carbamazepine can cause fetal harm: associated with congenital malformations including spina bifida, craniofacial and cardiovascular defects, and developmental delays; weigh benefits and risks and counsel women of childbearing potential; pregnancy registry enrolment encouraged.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Carbamazepine and its epoxide pass into breast milk (milk:plasma ratio about 0.4 and 0.5); decide whether to discontinue nursing or the drug, considering the importance of the drug to the mother.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Carbamazepine: Prolongs the inactivated state of voltage-sensitive neuronal sodium channels, reducing high-frequency repetitive firing.