سعر كاردورا إكس إل 4 مجم 28 قرص ممتد المفعول 2023

Cardura XL 4 mg prolonged-release tablets (Pfizer); Egyptian pack of 28 tablets. Doxazosin selective alpha-1 antagonist.

• Treatment of the signs and symptoms of benign prostatic hyperplasia (BPH).Population: Adults (males with BPH)DailyMed / FDA

• Most commonly reported adverse reactions in BPH trials: asthenia, headache, hypotension, dizziness. Discontinuations also related to dyspnea, postural hypotension, somnolence.International label, same formulation · DailyMed / FDA

• Known hypersensitivity to doxazosin, other quinazolines (e.g., prazosin, terazosin), or any inert ingredients.International label, same formulation · DailyMed / FDA

• Postural hypotension with or without syncope may occur, especially after the first dose or dose increase; warn patients and avoid situations where injury could result if syncope occurs.International label, same formulation · DailyMed / FDA
• Intraoperative Floppy Iris Syndrome (IFIS) has been observed during cataract surgery in some patients treated with alpha-1 blockers; inform the ophthalmologist.International label, same formulation · DailyMed / FDA
• Not recommended in severe hepatic impairment; use caution in mild–moderate hepatic impairment. Screen for prostate cancer before and during BPH therapy.International label, same formulation · DailyMed / FDA

• Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin)ModerateDoxazosin is a CYP3A4 substrate; exercise caution with strong CYP3A4 inhibitors.DailyMed / FDA
• PDE-5 inhibitorsMajorConcomitant use can cause additive blood-pressure lowering and symptomatic hypotension; initiate PDE-5 inhibitor at lowest dose.DailyMed / FDA

• CARDURA XL is not indicated for use in females or for hypertension. Limited available pregnancy data are insufficient to inform drug-associated risk of major birth defects or miscarriage. Animal studies at multiples of human exposure did not show adverse developmental outcomes at tested doses; postnatal development delayed at higher exposures in rats.International label, same formulation · DailyMed / FDA
• Doxazosin is present in human milk. Effects on the breastfed infant and on milk production are unknown.International label, same formulation · DailyMed / FDA

• Doxazosin: Selectively blocks postsynaptic alpha-1 adrenoceptors in vascular and prostatic smooth muscle, reducing peripheral resistance and urethral tone.