سعر كاريفالان 12.5/7.5 مجم 2026

Carivalan 12.5/7.5 mg film-coated tablets (carvedilol/ivabradine), Servier; 28 tablets.

• Substitution therapy in adults with normal sinus rhythm already controlled on concomitant ivabradine and carvedilol at the same doses for symptomatic chronic stable angina in CAD.Population: Adults — chronic stable anginaLes Laboratoires Servier — Carivalan SmPC
• Substitution therapy for chronic heart failure (NYHA II-IV) with systolic dysfunction, same prerequisites as above.Population: Adults — chronic HF systolic dysfunctionLes Laboratoires Servier — Carivalan SmPC

• Carvedilol: dizziness, headache, fatigue, hypotension common/very common; bradycardia, dyspnoea, GI effects common. Ivabradine: phosphenes very common; bradycardia common; AF reported.International label, same formulation · Les Laboratoires Servier — Carivalan SmPC

• Hypersensitivity to actives/excipients/other beta-blockers; severe hepatic impairment; acute/unstable HF; unstable or Prinzmetal angina; 2nd/3rd degree AV block; sick sinus syndrome; severe/symptomatic bradycardia <50 bpm; acute MI; cardiogenic shock; pacemaker-dependent; severe PVD; severe hypotension (<90/<50); COPD with obstruction; bronchospasm/asthma history; metabolic acidosis; untreated phaeochromocytoma; with verapamil/diltiazem; with strong CYP3A4 inhibitors; pregnancy/lactation/WOCBP without contraception.International label, same formulation · Les Laboratoires Servier — Carivalan SmPC

• Ivabradine has no proven CV outcome benefit in symptomatic stable angina alone — symptomatic use only. Monitor heart rate. Increased AF risk. Do not start if resting HR <50. Avoid abrupt beta-blocker withdrawal. Caution in diabetes, PVD, contact-lens users, psoriasis history.International label, same formulation · Les Laboratoires Servier — Carivalan SmPC

• Strong CYP3A4 inhibitors / verapamil / diltiazemMajorContraindicated with strong CYP3A4 inhibitors and with verapamil or diltiazem.Les Laboratoires Servier — Carivalan SmPC
• QT-prolonging medicinesMajorAvoid combination; HR reduction may exacerbate QT prolongation and arrhythmia risk.Les Laboratoires Servier — Carivalan SmPC
• Digoxin / digitalisModerateCarvedilol may increase digoxin levels and both slow AV conduction — monitor.Les Laboratoires Servier — Carivalan SmPC

• Contraindicated in pregnancy: beta-blockers reduce placental perfusion; ivabradine animal embryotoxicity/teratogenicity.International label, same formulation · Les Laboratoires Servier — Carivalan SmPC
• Contraindicated during breast-feeding; carvedilol/ivabradine excreted in animal milk.International label, same formulation · Les Laboratoires Servier — Carivalan SmPC

• Carvedilol:
• Ivabradine: Selectively inhibits the If ("funny") current in the sinoatrial node, slowing diastolic depolarisation and lowering heart rate without affecting contractility.