سعر كو-رينيتك 20/12.5 مجم 28 قرص 2022

Co-Renitec 20/12.5 mg tablets ×28: enalapril + hydrochlorothiazide (Global Napi / MSD).

• Indicated for the treatment of hypertension; fixed-dose combination is not for initial therapy (US VASERETIC label).Population: Adults with hypertensionDailyMed (U.S. National Library of Medicine)

• Most frequent in controlled trials: dizziness, headache, fatigue, cough; orthostatic effects, muscle cramps, nausea, impotence also reported (US VASERETIC label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Contraindicated in hypersensitivity to any component; history of ACE inhibitor–related, hereditary or idiopathic angioedema; anuria or sulfonamide hypersensitivity (HCTZ); with a neprilysin inhibitor (e.g. sacubitril) or within 36 hours of sacubitril/valsartan; and with aliskiren in diabetes (US VASERETIC label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning — fetal toxicity: discontinue as soon as pregnancy is detected; drugs acting on the renin-angiotensin system can cause injury and death to the developing fetus. Also: angioedema (including laryngeal), hypotension, hyperkalemia, renal impairment, HCTZ acute myopia/angle-closure glaucoma, and non-melanoma skin cancer risk with HCTZ (US VASERETIC label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Potassium-sparing diuretics / potassium supplements / salt substitutesMajorMay cause significant hyperkalemia with ACE inhibitor component; use cautiously with frequent potassium monitoring (US VASERETIC label).DailyMed (U.S. National Library of Medicine)
• LithiumMajorLithium toxicity reported with ACE inhibitors and thiazides; monitor serum lithium frequently if coadministered (US VASERETIC label).DailyMed (U.S. National Library of Medicine)

• Drugs that act on the renin-angiotensin system in the second and third trimesters reduce fetal renal function and increase fetal/neonatal morbidity and death; discontinue VASERETIC as soon as pregnancy is detected (US boxed warning / PLLR framing).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Enalapril, enalaprilat and hydrochlorothiazide are detected in human breast milk; decide whether to discontinue nursing or the drug given potential serious reactions in nursing infants (US VASERETIC label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Enalapril maleate: Inhibits ACE, reducing angiotensin II formation and aldosterone secretion, lowering peripheral resistance.
• Hydrochlorothiazide: Promotes renal excretion of sodium and chloride, reducing intravascular volume.