سعر لينوبريل-اتش 12.5/20 مجم 10 اقراص 2022

Linopril-H tablets, hydrochlorothiazide 12.5 mg + lisinopril 20 mg, pack of 10 (CID, Egypt); ACE inhibitor combined with a thiazide diuretic for hypertension.

• Hypertension, to lower blood pressure; not indicated for initial therapy.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most frequent in controlled trials: dizziness 7.5%, headache 5.2%, cough 3.9%, fatigue 3.7% and orthostatic effects 3.2%; discontinuation in 4.4%, mainly for dizziness, cough, fatigue and muscle cramps.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to the product; history of ACE-inhibitor-related angioedema; hereditary or idiopathic angioedema.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Anuria or hypersensitivity to sulfonamide-derived drugs (hydrochlorothiazide component).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Combination with a neprilysin inhibitor (sacubitril); do not give within 36 hours of switching to or from sacubitril/valsartan; aliskiren must not be co-administered in patients with diabetes.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning - fetal toxicity: drugs acting on the renin-angiotensin system can injure or kill the developing fetus; discontinue as soon as pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Head and neck or intestinal angioedema may occur at any time (higher rate in Black patients); stop promptly and treat; airway involvement can be fatal.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hyperkalaemia (about 1.4% in trials); risk with renal insufficiency, diabetes, potassium-sparing diuretics, potassium supplements or salt substitutes; also hypotension, renal function changes and cough.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Potassium-sparing diuretics, potassium supplements, potassium-containing salt substitutesIncrease risk of hyperkalaemia; use cautiously, if at all, with frequent potassium monitoring.DailyMed (U.S. National Library of Medicine)
• LithiumLithium generally should not be given with thiazides (and ACE inhibitors) because of toxicity risk.DailyMed (U.S. National Library of Medicine)

• When pregnancy is detected, discontinue as soon as possible: drugs acting directly on the renin-angiotensin system can cause fetal injury and death.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Thiazides appear in human milk and lisinopril is present in rat milk; decide whether to stop nursing or the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hydrochlorothiazide: Promotes renal excretion of sodium and chloride, reducing intravascular volume.
• Lisinopril: Inhibits angiotensin-converting enzyme, reducing angiotensin II formation and aldosterone secretion.