سعر كولميديتين 0.5مجم 100 قرص 2024

Colmediten 0.5mg 100 tabs: Colchicine 0.5 mg (Kahira).

• US LODOCO (colchicine 0.5 mg): indicated to reduce risk of MI, stroke, coronary revascularization, and cardiovascular death in adults with established atherosclerotic disease or multiple CV risk factors — NOT automatically applicable to Egyptian Colmediten antigout presentation.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Common: diarrhea, vomiting, abdominal cramping, myalgia. Serious: blood dyscrasias, neuromuscular toxicity/rhabdomyolysis, acute renal impairment (US LODOCO / colchicine literature).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• US LODOCO: contraindicated with strong CYP3A4 or P-gp inhibitors; renal failure (CrCl <15 mL/min); severe hepatic impairment; pre-existing blood dyscrasias; hypersensitivity to colchicine.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Blood dyscrasias (myelosuppression, pancytopenia, aplastic anemia) and neuromuscular toxicity/rhabdomyolysis can occur; GI symptoms often first sign of toxicity. Caution with moderate CYP3A4 inhibitors and in any renal/hepatic impairment (US LODOCO).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inhibitors (e.g. clarithromycin, ketoconazole, ritonavir)MajorContraindicated: significant increases in colchicine levels; life-threatening toxicity reported.DailyMed (U.S. National Library of Medicine)
• P-gp inhibitors (e.g. cyclosporine, ranolazine)MajorContraindicated with strong P-gp inhibitors per US LODOCO.DailyMed (U.S. National Library of Medicine)
• Grapefruit / grapefruit juiceModerateIncreases colchicine exposure; advise avoidance (US LODOCO).DailyMed (U.S. National Library of Medicine)

• US LODOCO PLLR: published human data over decades have not identified drug-associated major birth defect/miscarriage risks; colchicine crosses placenta; animal data show embryofetal toxicity at clinical-range exposures.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Present in human milk; adverse events in breastfed infants generally not reported; reconsider if infant has diarrhea (US LODOCO).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Colchicine: Disrupts β-tubulin polymerization into microtubules; inhibits neutrophil activation/migration; may interfere with inflammasome/IL-1β.