سعر جاوريست 0.5مجم 100 قرص 2024

Colchicine 0.5 mg tablets (Pharopharma), 10 strips x 10 tablets per pack.

• Treatment of acute gout.Population: Adultselectronic medicines compendium (emc), UK
• Prophylaxis of gout flares during initiation of allopurinol or uricosuric therapy.Population: Adultselectronic medicines compendium (emc), UK

• UK: common: abdominal pain, nausea, vomiting and diarrhoea; also reported: bone marrow depression, peripheral neuropathy, myopathy and alopecia.International label, equivalent formulation · electronic medicines compendium (emc), UK

• UK: hypersensitivity; blood dyscrasias; pregnancy; breastfeeding; women of childbearing potential not using effective contraception; severe renal or hepatic impairment; haemodialysis; renal or hepatic impairment with concomitant P-gp or strong CYP3A4 inhibitors.International label, equivalent formulation · electronic medicines compendium (emc), UK

• UK: narrow therapeutic window; stop treatment if gastrointestinal toxicity (nausea, vomiting, abdominal pain, diarrhoea) occurs; bone marrow depression (agranulocytosis, aplastic anaemia, thrombocytopenia) may occur, so periodic blood counts are needed.International label, equivalent formulation · electronic medicines compendium (emc), UK

• CYP3A4 / P-glycoprotein inhibitors (e.g. clarithromycin, erythromycin, ciclosporin, ketoconazole, itraconazole, HIV protease inhibitors, verapamil, diltiazem)MajorUK: increased colchicine toxicity; reduce colchicine dose (about 4-fold with strong CYP3A4 or P-gp inhibitors, 2-fold with moderate CYP3A4 inhibitors); contraindicated with these inhibitors in renal or hepatic impairment; avoid grapefruit juice.electronic medicines compendium (emc), UK
• Statins, fibrates, ciclosporin, digoxinUK: increased risk of myopathy and rhabdomyolysis when combined with colchicine.electronic medicines compendium (emc), UK

• UK: colchicine is contraindicated in pregnancy.International label, equivalent formulation · electronic medicines compendium (emc), UK
• UK: colchicine is contraindicated during breastfeeding.International label, equivalent formulation · electronic medicines compendium (emc), UK

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