سعر كولشيسين 500مكجم 100 قرص 2024

Colchicine 500 mcg tablets (El Nasr).

• Prophylaxis of gout flares in adults (US MITIGARE). Not an analgesic for other pain.Population: Adults — gout flare prophylaxisDailyMed (U.S. National Library of Medicine)

• Most common: diarrhea, nausea, vomiting, abdominal pain (US MITIGARE).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Do not give with dual P-gp and CYP3A4 inhibitors in renal or hepatic impairment; do not give if both renal and hepatic impairment (US MITIGARE).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Fatal overdoses; blood dyscrasias; life-threatening CYP3A4/P-gp interactions; neuromuscular toxicity/rhabdomyolysis (US MITIGARE).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• CYP3A4 inhibitors (clarithromycin, ketoconazole, grapefruit, etc.)MajorAvoid if possible; otherwise reduce dose and monitor toxicity (US MITIGARE).DailyMed (U.S. National Library of Medicine)
• P-gp inhibitors (cyclosporine, clarithromycin, etc.)MajorAvoid if possible; dose reduction and monitoring if coadministered (US MITIGARE).DailyMed (U.S. National Library of Medicine)
• Statins / fibratesModerateIncreased myopathy risk; evaluate muscle symptoms/CK (US MITIGARE).DailyMed (U.S. National Library of Medicine)

• Published data have not identified clear drug-associated major birth-defect risk in some rheumatic cohorts; use if benefit justifies risk (US MITIGARE).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Present in human milk; many published reports without infant adverse effects; weigh benefits/risks (US MITIGARE).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Colchicine: Disrupts microtubule polymerization; reduces neutrophil migration in crystal inflammation.