سعر ديجليفلوز بلس 5/1000 مجم 30 قرص مغلف 2024

Diglifloz plus 5/1000mg 30 f.c. tabs — Dapagliflozin + metformin (Marcyrl).

• Adjunct to diet and exercise to improve glycemic control in T2DM (adults and pediatrics ≥10 y) (US FARXIGA).Population: T2DM ≥10 yearsDailyMed
• Reduce risk of eGFR decline/ESKD/CV death/hHF in CKD; CV death/hHF/urgent HF visit in HF; hHF in T2DM with CV disease/risk (US FARXIGA 10 mg indication set — confirm Egyptian label).Population: Adults per US labelDailyMed

• Common (≥5%): female genital mycotic infections, nasopharyngitis, UTI (US FARXIGA).International label, equivalent formulation · DailyMed

• Serious hypersensitivity to dapagliflozin or excipients (US FARXIGA).International label, equivalent formulation · DailyMed

• Ketoacidosis risk; assess ketones if suspected regardless of glucose (US FARXIGA).International label, equivalent formulation · DailyMed
• Volume depletion; GU infections including Fournier’s gangrene; hypoglycemia with insulin/secretagogues (US FARXIGA).International label, equivalent formulation · DailyMed
• Metformin: lactic acidosis risk — follow metformin renal/hypoxia/alcohol cautions (ingredient-level; Egyptian Diglifloz Plus leaflet not opened).Per the manufacturer

• Insulin or insulin secretagoguesModerateIncreased hypoglycemia risk.; Consider lower insulin/secretagogue dose.DailyMed

• Not recommended in 2nd/3rd trimester (animal renal developmental toxicity) (US FARXIGA).International label, equivalent formulation · DailyMed
• Not recommended while breastfeeding (US FARXIGA).International label, equivalent formulation · DailyMed

• Dapagliflozin: Inhibits SGLT2 in proximal renal tubules, reducing glucose reabsorption and promoting urinary glucose excretion; also increases sodium delivery to the distal tubule.
• Metformin: Decreases hepatic glucose production, decreases intestinal glucose absorption and improves insulin sensitivity by increasing peripheral glucose uptake and utilization; insulin secretion remains unchanged (US label).