سعر فورمينوداب إكس آر 10/1000 مجم 30 قرص ممتد المفعول 2023

Dapagliflozin 10 mg / metformin HCl 1000 mg extended-release film-coated tablets (30 tablets).

• Adjunct to diet and exercise to improve glycaemic control in adults and children 10 years and older with type 2 diabetes.Population: Adults and children >=10 yearsDailyMed (U.S. NLM)
• In adults with type 2 diabetes, the dapagliflozin component reduces the risk of kidney-disease progression, cardiovascular death and heart-failure hospitalisation (CKD, heart failure, or established CV disease/multiple risk factors).Population: Adults with type 2 diabetesDailyMed (U.S. NLM)

• Most common (>5%): female genital mycotic infection, nasopharyngitis, urinary tract infection, diarrhoea and headache; with metformin XR: diarrhoea and nausea/vomiting.International label, same formulation · DailyMed (U.S. NLM)

• Severe renal impairment (eGFR <30) or end-stage renal disease; serious hypersensitivity to dapagliflozin, metformin or excipients; acute or chronic metabolic acidosis including diabetic ketoacidosis.International label, same formulation · DailyMed (U.S. NLM)

• Boxed warning: metformin-associated lactic acidosis (risk factors: renal or hepatic impairment, age >=65, contrast studies, surgery, hypoxic states, excess alcohol, carbonic anhydrase inhibitors); discontinue and hospitalise if suspected.International label, same formulation · DailyMed (U.S. NLM)
• Ketoacidosis, volume depletion/acute kidney injury, serious genitourinary infections including Fournier gangrene, genital mycotic infections, hypoglycaemia with insulin/secretagogues, and vitamin B12 deficiency.International label, same formulation · DailyMed (U.S. NLM)

• Carbonic anhydrase inhibitors (topiramate, zonisamide, acetazolamide)May increase lactic acidosis risk; monitor more frequently.DailyMed (U.S. NLM)
• OCT2/MATE inhibitors (ranolazine, vandetanib, dolutegravir, cimetidine)Increase metformin exposure and lactic acidosis risk; weigh benefits and risks.DailyMed (U.S. NLM)
• AlcoholPotentiates metformin effect on lactate; avoid excessive intake.DailyMed (U.S. NLM)

• Not recommended in the second and third trimesters (adverse renal effects of dapagliflozin in rats); published metformin data show no clear association with major birth defects or miscarriage.International label, same formulation · DailyMed (U.S. NLM)
• Not recommended while breastfeeding: metformin is present in human milk and dapagliflozin in rat milk, with potential risk to the developing infant kidney.International label, same formulation · DailyMed (U.S. NLM)

• Dapagliflozin: Inhibits renal SGLT2, reducing glucose reabsorption and increasing urinary glucose excretion.
• Metformin: Decreases hepatic glucose production and intestinal absorption and improves insulin sensitivity.