سعر ابيسيفين 500مجم فيال عضل 2022

Epicephin 500mg i.m. vial: Ceftriaxone 500 mg powder for intramuscular injection, 1 vial (EIPICO, Egypt).

• Treatment of the following infections in adults and children including term neonates: bacterial meningitis; community-acquired pneumonia; hospital-acquired pneumonia; acute otitis media; intra-abdominal infections; complicated urinary tract infections including pyelonephritis; infections of bones and joints; complicated skin and soft tissue infections; gonorrhoea; syphilis; bacterial endocarditis. May also be used for acute exacerbations of COPD in adults, disseminated Lyme borreliosis (early stage II and late stage III) in adults and children including neonates from 15 days of age, pre-operative prophylaxis of surgical site infections, and management of neutropenic patients with fever suspected to be due to a bacterial infection (EIPICO product page).Population: Adults and children including term neonatesEIPICO (Egyptian International Pharmaceutical Industries Co.)
• US-labelled uses: lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, urinary tract infections, uncomplicated gonorrhea, pelvic inflammatory disease, bacterial septicemia, bone and joint infections, intra-abdominal infections, meningitis, and surgical prophylaxis (US label).Population: Adults and pediatric patients as labeledDailyMed (U.S. National Library of Medicine)

• Reported adverse reactions include eosinophilia (6%), thrombocytosis (5.1%), diarrhea (2.7%), elevated ALT (3.3%) and AST (3.1%), leukopenia (2.1%), rash (1.7%), elevated BUN (1.2%), and local pain/induration at the injection site (1%); phlebitis after IV use (<1%) (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to ceftriaxone, any of its excipients, or any other cephalosporin (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Neonates: contraindicated in premature neonates up to a postmenstrual age of 41 weeks, in hyperbilirubinemic neonates, and in neonates ≤28 days who require (or are expected to require) calcium-containing IV solutions (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Serious hypersensitivity reactions including anaphylaxis may occur; use with caution in patients with penicillin allergy because of possible cross-sensitivity (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Ceftriaxone-calcium precipitation: do not mix with or administer simultaneously with calcium-containing IV solutions via the same line; in patients other than neonates sequential administration is possible if the line is thoroughly flushed between infusions (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhea, immune-mediated hemolytic anemia (including fatal cases), gallbladder pseudolithiasis, pancreatitis and neurological reactions (encephalopathy, seizures, especially in severe renal impairment) have been reported (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Calcium-containing IV solutionsMajorRisk of ceftriaxone-calcium precipitation; contraindicated in neonates ≤28 days and must not be given simultaneously via the same line in other patients (US label).DailyMed (U.S. National Library of Medicine)
• Vitamin K antagonists (e.g., warfarin)ModerateMay increase bleeding risk; monitor coagulation parameters frequently and adjust the anticoagulant dose as needed (US label).DailyMed (U.S. National Library of Medicine)

• Animal reproduction studies showed no evidence of harm at multiples of the human dose; there are no adequate and well-controlled studies in pregnant women — use during pregnancy only if clearly needed (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Low concentrations of ceftriaxone are excreted in human milk; use with caution in nursing women (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

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