سعر ابيفيناك 25 مجم 5 اقماع 2025

Epifenac (diclofenac sodium) 25 mg rectal suppositories, box of 5, EIPICO; NSAID.

• Adults: relief of pain and inflammation in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout, acute musculoskeletal disorders, and pain and inflammation after trauma or surgery.Population: Adultselectronic medicines compendium (emc)
• Children 1-12 years: juvenile chronic arthritis.Population: Children 1-12 yearselectronic medicines compendium (emc)
• Children 6 years and over: acute post-operative pain (short-term).Population: Children >=6 yearselectronic medicines compendium (emc)

• Common: headache, dizziness, vertigo, nausea, vomiting, diarrhoea, dyspepsia, abdominal pain, flatulence, anorexia, raised transaminases and rash.International label, same formulation · electronic medicines compendium (emc)

• Proctitis (rectal inflammation).International label, same formulation · electronic medicines compendium (emc)
• Hypersensitivity to diclofenac or excipients; active or history of recurrent peptic ulcer, GI bleeding or perforation; third trimester of pregnancy; hepatic or renal failure; established congestive heart failure (NYHA II-IV), ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease; asthma, urticaria or rhinitis precipitated by aspirin or other NSAIDs.International label, same formulation · electronic medicines compendium (emc)

• Gastrointestinal bleeding, ulceration or perforation, which can be fatal, may occur at any time; use the lowest effective dose for the shortest duration.International label, same formulation · electronic medicines compendium (emc)
• Increased risk of arterial thrombotic events (myocardial infarction, stroke), particularly at 150 mg daily and with long-term use.International label, same formulation · electronic medicines compendium (emc)
• Hepatic enzyme elevations and hepatitis may occur; renal impairment and fluid retention may occur, especially in the elderly or with diuretics.International label, same formulation · electronic medicines compendium (emc)

• Lithium and digoxinDiclofenac may raise plasma concentrations; monitor levels.electronic medicines compendium (emc)
• Diuretics and antihypertensives (ACE inhibitors, beta-blockers)Reduced antihypertensive effect and increased risk of renal impairment; potassium-sparing diuretics may raise serum potassium.electronic medicines compendium (emc)
• Anticoagulants, antiplatelet agents and SSRIsIncreased risk of bleeding.electronic medicines compendium (emc)

• Do not use in the first and second trimesters unless clearly necessary; from week 20 onwards NSAID use may cause oligohydramnios from fetal renal dysfunction.International label, same formulation · electronic medicines compendium (emc)
• Small amounts pass into breast milk; avoid while breastfeeding.International label, same formulation · electronic medicines compendium (emc)

• Diclofenac sodium: Inhibits prostaglandin synthesis through inhibition of cyclo-oxygenase (COX-1 and COX-2).