سعر يوبيزار 1 جم فيال 2025

Gemcitabine 1 g for intravenous infusion, single vial.

• Advanced ovarian cancer that has relapsed at least 6 months after platinum-based therapy, in combination with carboplatin.DailyMed (U.S. NLM)
• Metastatic breast cancer after failure of prior anthracycline-containing adjuvant chemotherapy, in combination with paclitaxel.DailyMed (U.S. NLM)
• Inoperable locally advanced or metastatic non-small cell lung cancer, in combination with cisplatin.DailyMed (U.S. NLM)

• Most common adverse reactions (20% or more) as a single agent: nausea/vomiting, anemia, increased ALT and AST, neutropenia, increased alkaline phosphatase, proteinuria, fever, hematuria, rash, thrombocytopenia, dyspnea and edema.International label, equivalent formulation · DailyMed (U.S. NLM)

• Known hypersensitivity to gemcitabine.International label, equivalent formulation · DailyMed (U.S. NLM)

• Schedule-dependent toxicity (infusion longer than 60 minutes or more often than weekly increases toxicity); myelosuppression; pulmonary toxicity and respiratory failure; hemolytic uremic syndrome; hepatotoxicity; embryo-fetal toxicity; exacerbation of radiation therapy toxicity; capillary leak syndrome; posterior reversible encephalopathy syndrome.International label, equivalent formulation · DailyMed (U.S. NLM)

• Can cause fetal harm; advise females of reproductive potential to use effective contraception during treatment and for 6 months after the last dose, and males with female partners for 3 months after the last dose.International label, equivalent formulation · DailyMed (U.S. NLM)
• Advise women not to breastfeed during treatment and for at least 1 week after the last dose.International label, equivalent formulation · DailyMed (U.S. NLM)

• Gemcitabine: Nucleoside metabolic inhibitor; after intracellular phosphorylation its di- and triphosphate metabolites inhibit ribonucleotide reductase and DNA synthesis; it kills cells undergoing DNA synthesis and blocks progression through the G1/S-phase boundary (US gemcitabine label).