سعر تابين 1جم فيال وريد.تحت الجلد 2024

Tabine (cytarabine) 1 vial (1 g cytarabine), Hikma Specialized Pharmaceuticals, Egypt; cytotoxic antimetabolite used in acute leukaemias, for IV, SC or intrathecal use per its name.

• Remission induction in acute non-lymphocytic leukaemia (adults and children), in combination with other anticancer drugsPopulation: Adults and childrenDailyMed (U.S. National Library of Medicine)
• Acute lymphocytic leukaemia and blast phase of chronic myelocytic leukaemiaDailyMed (U.S. National Library of Medicine)
• Intrathecal prophylaxis and treatment of meningeal leukaemia (preservative-free only)DailyMed (U.S. National Library of Medicine)

• Expected myelosuppression (anaemia, leukopenia, thrombocytopenia, megaloblastosis); most frequent: anorexia, nausea, vomiting, diarrhoea, oral/anal inflammation or ulceration, hepatic dysfunction, fever, rash, thrombophlebitis, bleeding.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Cytarabine (ara-C) syndrome 6-12 hours after dosing: fever, myalgia, bone pain, rash, conjunctivitis, malaise; corticosteroids may help.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to cytarabine.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: only physicians experienced in cancer chemotherapy should use it; main toxicity is bone marrow suppression (leukopenia, thrombocytopenia, anaemia).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Anaphylaxis with cardiopulmonary arrest has been reported; experimental high-dose schedules caused severe, sometimes fatal CNS, GI and pulmonary toxicity.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• May cause hyperuricaemia from tumour lysis; acute pancreatitis has been reported.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• DigoxinReversible decreases in steady-state digoxin levels with combination chemotherapy including cytarabine; monitor digoxin levels.DailyMed (U.S. National Library of Medicine)
• GentamicinIn vitro antagonism of gentamicin activity against K. pneumoniae; reassess therapy if response is slow.DailyMed (U.S. National Library of Medicine)
• FlucytosinePossible inhibition of flucytosine efficacy.DailyMed (U.S. National Library of Medicine)

• Can cause fetal harm; teratogenic in animals; women of childbearing potential should avoid pregnancy. Risk is highest with first-trimester exposure and reduced but definite in the second and third trimesters.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Unknown whether excreted in human milk; because of potential serious adverse reactions in the infant, decide whether to discontinue nursing or the drug.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Cytarabine: S-phase-specific cytotoxic nucleoside analogue: converted intracellularly to ara-CTP, which inhibits DNA polymerase and is incorporated into DNA; inactivated by cytidine deaminase to ara-U.