سعر فيم 7-100 ميكروغرام 4 لصقات عبر الجلد 2022

Estradiol once-weekly transdermal patch releasing 100 micrograms estradiol per 24 hours (Merck KGaA), 4 patches.

• Hormone replacement therapy for oestrogen-deficiency symptoms in postmenopausal women.Population: Postmenopausal womenelectronic medicines compendium (emc), UK
• Prevention of osteoporosis in postmenopausal women at high risk of fractures who are intolerant of, or contraindicated for, other osteoporosis-prevention medicines.Population: Postmenopausal womenelectronic medicines compendium (emc), UK
• Moderate to severe vasomotor symptoms and vulvar/vaginal atrophy due to menopause; hypoestrogenism; prevention of postmenopausal osteoporosis.Population: WomenDailyMed (U.S. National Library of Medicine)

• Application-site reactions (pruritus, erythema, eczema, urticaria, oedema, pigmentation changes) are the most frequent (>10%); also headache, breast discomfort/tenderness, nausea, abdominal pain, breakthrough bleeding, vaginal discharge, mood changes, oedema and weight changes.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Known, past or suspected breast cancer; oestrogen-dependent malignant tumours; undiagnosed genital bleeding; untreated endometrial hyperplasia; previous or current venous thromboembolism; known thrombophilic disorders; active or recent arterial thromboembolic disease; acute or past liver disease with abnormal liver tests; hypersensitivity; porphyria.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Start HRT only for symptoms affecting quality of life and reassess at least annually. Oestrogen-alone therapy increases endometrial hyperplasia/cancer risk in women with a uterus (add a progestogen); HRT is associated with increased risks of venous thromboembolism (1.3-3-fold), breast cancer, ovarian cancer and ischaemic stroke.International label, equivalent formulation · electronic medicines compendium (emc), UK
• US boxed warning: endometrial cancer with unopposed oestrogen, cardiovascular disorders, probable dementia and breast cancer; do not use oestrogens to prevent cardiovascular disease or dementia.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Enzyme inducers (phenobarbital, phenytoin, carbamazepine, rifampicin, rifabutin, nevirapine, efavirenz, ritonavir, nelfinavir, St John's wort)May increase oestrogen metabolism, reducing effect and altering the bleeding profile (transdermal route less affected than oral).electronic medicines compendium (emc), UK
• LamotrigineOestrogens may lower lamotrigine levels (glucuronidation induction), possibly reducing seizure control.electronic medicines compendium (emc), UK

• Not indicated during pregnancy; withdraw immediately if pregnancy occurs. Most epidemiological data on inadvertent foetal oestrogen exposure show no teratogenic or foetotoxic effects.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Not indicated during lactation; oestrogens are present in human milk and can reduce milk production.International label, equivalent formulation · electronic medicines compendium (emc), UK, DailyMed (U.S. National Library of Medicine)

• Estradiol (as estradiol hemihydrate): Synthetic 17β-estradiol, identical to endogenous estradiol; replaces the loss of ovarian oestrogen production after menopause and relieves menopausal symptoms.