سعر فروسيتون 20/100مجم 10 قرص 2022

Film-coated tablets combining furosemide 20 mg (loop diuretic) with spironolactone 100 mg (aldosterone antagonist), made by Pharco; pack of 10 tablets.

• Combination: hyponatraemia (common), increased urine volume, urinary retention with outflow obstruction, renal failure, headache, nausea, vomiting, diarrhoea, raised liver enzymes.General active-ingredient information · Sanofi India Limited
• Furosemide: electrolyte disturbances, dehydration and hypovolaemia (very common), hypokalaemia, hypocalcaemia, hypomagnesaemia, raised uric acid and gout, impaired glucose tolerance, hypotension, pancreatitis, hearing disorders and tinnitus, blood dyscrasias and severe skin reactions (SJS/TEN, AGEP, DRESS).General active-ingredient information · Sanofi India Limited
• Spironolactone: hyperkalaemia (especially with renal impairment), breast tenderness and enlargement (including in men), menstrual irregularities, erectile dysfunction, hirsutism, drowsiness, ataxia, gastric ulceration and voice changes.General active-ingredient information · Sanofi India Limited

• Hypovolaemia or dehydration; hyperkalaemia; severe hypokalaemia; severe hyponatraemia.General active-ingredient information · Sanofi India Limited
• Pregnancy (spironolactone component) and breastfeeding.General active-ingredient information · Sanofi India Limited
• Hypersensitivity to furosemide, spironolactone or any excipient; patients allergic to sulfonamides may show cross-sensitivity to furosemide.General active-ingredient information · Sanofi India Limited

• Urinary outflow must be secured; patients with partial urinary outflow obstruction (e.g. prostatic hyperplasia) need careful monitoring, especially at the start of treatment.General active-ingredient information · Sanofi India Limited
• Hypovolaemia, dehydration and electrolyte or acid-base disturbances must be corrected; careful monitoring is needed in hypotension, coronary or cerebral artery stenosis, diabetes, gout, hepatorenal syndrome and hypoproteinaemia.General active-ingredient information · Sanofi India Limited
• Furosemide may exacerbate or activate systemic lupus erythematosus. Higher mortality was seen in elderly patients with dementia given furosemide with risperidone; weigh risks before co-use.General active-ingredient information · Sanofi India Limited
• Spironolactone can cause voice changes (hoarseness, deepening or raising of the voice) that may persist after stopping; it binds the androgen receptor and may raise PSA, and tumour progression was seen in some patients with metastatic castration-resistant prostate cancer.General active-ingredient information · Sanofi India Limited

• ACE inhibitors / angiotensin II receptor antagonistsSevere hypotension and worsening renal function can occur, especially when starting or increasing these drugs; with spironolactone they also raise the risk of severe hyperkalaemia.Sanofi India Limited
• Potassium salts, potassium-sparing drugs and NSAIDsCombination with spironolactone may cause severe hyperkalaemia; NSAIDs including aspirin may also reduce the diuretic effect and cause acute renal failure in dehydrated patients.Sanofi India Limited
• LithiumFurosemide reduces lithium excretion and may raise lithium levels and toxicity; monitor lithium levels.Sanofi India Limited
• Aminoglycosides, cisplatin and other ototoxic drugsFurosemide may potentiate ototoxicity, which may be irreversible.Sanofi India Limited
• DigoxinSpironolactone may raise blood digoxin levels; electrolyte disturbances increase digitalis toxicity.Sanofi India Limited
• Abiraterone / mitotaneUse with abiraterone is not recommended (spironolactone may raise PSA); spironolactone may reduce mitotane levels and should not be combined with it.Sanofi India Limited

• Must not be given during pregnancy. Furosemide crosses the placenta; spironolactone caused feminisation of male offspring in animal studies, and anti-androgenic effects with a risk of genital ambiguity in newborn males have been reported.General active-ingredient information · Sanofi India Limited
• Contraindicated during breastfeeding; furosemide passes into breast milk and inhibits lactation.General active-ingredient information · Sanofi India Limited

• Regular monitoring of serum sodium, potassium and creatinine; more frequent potassium checks when creatinine clearance is below 60 ml/min or with drugs that raise potassium.General active-ingredient information · Sanofi India Limited

• Furosemide: Inhibits the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, reducing reabsorption of sodium and water.
• Spironolactone: Long-acting aldosterone antagonist (as described in the Lasilactone label); it also binds the androgen receptor.