سعر فروزيتون 20/50 مجم 10 اقراص 2022

Film-coated tablets combining furosemide 20 mg (loop diuretic) with spironolactone 50 mg (aldosterone antagonist), made by Pharco; pack of 10 tablets.

• Resistant oedema associated with secondary hyperaldosteronism, including chronic congestive cardiac failure and hepatic cirrhosis, in cases refractory to a diuretic alone.Population: AdultsSanofi India Limited
• Essential hypertension only in patients with demonstrated hyperaldosteronism, and only if titration with the separate components shows this fixed combination is appropriate.Population: AdultsSanofi India Limited

• Combination: hyponatraemia (common), increased urine volume, urinary retention with outflow obstruction, renal failure, headache, nausea, vomiting, diarrhoea, raised liver enzymes.International label, same formulation · Sanofi India Limited
• Furosemide: electrolyte disturbances, dehydration and hypovolaemia (very common), hypokalaemia, hypocalcaemia, hypomagnesaemia, raised uric acid and gout, impaired glucose tolerance, hypotension, pancreatitis, hearing disorders and tinnitus, blood dyscrasias and severe skin reactions (SJS/TEN, AGEP, DRESS).International label, same formulation · Sanofi India Limited
• Spironolactone: hyperkalaemia (especially with renal impairment), breast tenderness and enlargement (including in men), menstrual irregularities, erectile dysfunction, hirsutism, drowsiness, ataxia, gastric ulceration and voice changes.International label, same formulation · Sanofi India Limited

• Hypovolaemia or dehydration; hyperkalaemia; severe hypokalaemia; severe hyponatraemia.International label, same formulation · Sanofi India Limited
• Pregnancy (spironolactone component) and breastfeeding.International label, same formulation · Sanofi India Limited
• Hypersensitivity to furosemide, spironolactone or any excipient; patients allergic to sulfonamides may show cross-sensitivity to furosemide.International label, same formulation · Sanofi India Limited

• Urinary outflow must be secured; patients with partial urinary outflow obstruction (e.g. prostatic hyperplasia) need careful monitoring, especially at the start of treatment.International label, same formulation · Sanofi India Limited
• Hypovolaemia, dehydration and electrolyte or acid-base disturbances must be corrected; careful monitoring is needed in hypotension, coronary or cerebral artery stenosis, diabetes, gout, hepatorenal syndrome and hypoproteinaemia.International label, same formulation · Sanofi India Limited
• Furosemide may exacerbate or activate systemic lupus erythematosus. Higher mortality was seen in elderly patients with dementia given furosemide with risperidone; weigh risks before co-use.International label, same formulation · Sanofi India Limited

• ACE inhibitors / angiotensin II receptor antagonistsSevere hypotension and worsening renal function can occur, especially when starting or increasing these drugs; with spironolactone they also raise the risk of severe hyperkalaemia.Sanofi India Limited
• Potassium salts, potassium-sparing drugs and NSAIDsCombination with spironolactone may cause severe hyperkalaemia; NSAIDs including aspirin may also reduce the diuretic effect and cause acute renal failure in dehydrated patients.Sanofi India Limited
• LithiumFurosemide reduces lithium excretion and may raise lithium levels and toxicity; monitor lithium levels.Sanofi India Limited

• Must not be given during pregnancy. Furosemide crosses the placenta; spironolactone caused feminisation of male offspring in animal studies, and anti-androgenic effects with a risk of genital ambiguity in newborn males have been reported.International label, same formulation · Sanofi India Limited
• Contraindicated during breastfeeding; furosemide passes into breast milk and inhibits lactation.International label, same formulation · Sanofi India Limited

• Furosemide: Inhibits the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, reducing reabsorption of sodium and water.
• Spironolactone: Long-acting aldosterone antagonist (as described in the Lasilactone label); it also binds the androgen receptor.