سعر جاردوفاس 5مجم 30 قرص 2025

Ambrisentan 5 mg film-coated tablets (30 tablets), an endothelin receptor antagonist for pulmonary arterial hypertension, marketed in Egypt by Aug Pharma.

• Pulmonary arterial hypertension (WHO Group 1) in adults, to improve exercise ability and delay clinical worsening.Population: AdultsDailyMed (U.S. National Library of Medicine)
• In combination with tadalafil, to reduce the risks of disease progression and hospitalization for worsening PAH, and to improve exercise ability.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common: peripheral edema, nasal congestion, sinusitis and flushing; with tadalafil also headache, cough, anemia, dyspepsia and bronchitis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Pregnancy (may cause major birth defects).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Idiopathic pulmonary fibrosis, including IPF with pulmonary hypertension (WHO Group 3).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning, embryo-fetal toxicity: exclude pregnancy before starting; females of reproductive potential must use effective contraception before, during and for one month after treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Fluid retention and peripheral edema; heart failure may occur. Pulmonary edema suggests pulmonary veno-occlusive disease (stop if confirmed). Decreased sperm counts. Decreases in hemoglobin (not recommended in clinically significant anemia).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• CyclosporineAbout 2-fold increase in ambrisentan exposure; limit ambrisentan to 5 mg once daily.DailyMed (U.S. National Library of Medicine)

• Contraindicated in pregnancy: animal studies show birth defects and fetal death; human data are limited.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Unknown whether ambrisentan is present in human milk; decide whether to stop breastfeeding or the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Ambrisentan: Endothelin receptor antagonist selective for the ETA receptor; blocks endothelin-1-mediated vasoconstriction and proliferation in the pulmonary vasculature (US Letairis label, section 12.1).