سعر اندوسنتانا 5 مجم 10 اقراص 2022

Ambrisentan 5 mg film-coated tablets, 10 tablets (Rameda Endosentana).

• Treatment of pulmonary arterial hypertension (WHO Group 1) in adults to improve exercise ability and delay clinical worsening; in combination with tadalafil to reduce risks of disease progression and hospitalization for worsening PAH and to improve exercise ability.Population: AdultsDailyMed (U.S. NLM)

• Most common (>3% vs placebo): peripheral edema, nasal congestion, sinusitis and flushing.International label, same formulation · DailyMed (U.S. NLM)

• Pregnancy (may cause major birth defects); idiopathic pulmonary fibrosis.International label, same formulation · DailyMed (U.S. NLM)

• Boxed warning: embryo-fetal toxicity - exclude pregnancy before starting, use effective contraception before, during and for one month after treatment. Also: fluid retention; pulmonary edema suggesting pulmonary veno-occlusive disease; decreased sperm count; decreases in hemoglobin.International label, same formulation · DailyMed (U.S. NLM)

• CyclosporineApproximately 2-fold increase in ambrisentan exposure; limit ambrisentan to 5 mg once daily.DailyMed (U.S. NLM)

• Contraindicated in pregnancy: animal data show birth defects and fetal death; human data are limited.International label, same formulation · DailyMed (U.S. NLM)
• Unknown whether ambrisentan is present in human milk; decide whether to discontinue breastfeeding or the drug.International label, same formulation · DailyMed (U.S. NLM)

• Ambrisentan: Blocks endothelin receptor type A (ETA), counteracting endothelin-1-mediated pulmonary vasoconstriction (directory description; endothelin receptor antagonist class per US label).