سعر اوبسوميت 10 مجم أقراص 2026

Opsumit macitentan 10 mg film-coated tablets, pack of 30; manufactured by Patheon Italia, distributed in Egypt via Janssen scientific office.

• Treatment of pulmonary arterial hypertension (PAH, WHO Group I) in adults to reduce the risks of disease progression and hospitalization.DailyMed (U.S. National Library of Medicine)

• Most common (more frequent than placebo by at least 3%): anemia, nasopharyngitis/pharyngitis, bronchitis, headache, influenza and urinary tract infection.International label, same product · DailyMed (U.S. National Library of Medicine)

• Pregnancy (may cause fetal harm); history of hypersensitivity to macitentan or any component.International label, same product · DailyMed (U.S. National Library of Medicine)

• Embryo-fetal toxicity (boxed warning): exclude pregnancy before starting, use effective contraception during and for one month after treatment.International label, same product · DailyMed (U.S. National Library of Medicine)
• Hepatotoxicity (obtain baseline liver enzymes), fluid retention, decreases in hemoglobin, pulmonary edema in pulmonary veno-occlusive disease, and decreased sperm count.International label, same product · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inducers (e.g. rifampin)Reduce macitentan exposure; avoid co-administration.DailyMed (U.S. National Library of Medicine)
• Strong CYP3A4 inhibitors (e.g. ketoconazole, ritonavir)Approximately double macitentan exposure; avoid co-administration.DailyMed (U.S. National Library of Medicine)
• Moderate dual CYP3A4/CYP2C9 inhibitors (e.g. fluconazole, amiodarone)May increase macitentan exposure; avoid co-administration.DailyMed (U.S. National Library of Medicine)

• Contraindicated in pregnancy: teratogenic in animals; may cause fetal harm including birth defects and fetal death.International label, same product · DailyMed (U.S. National Library of Medicine)
• No data on presence in human milk; advise women not to breastfeed during treatment.International label, same product · DailyMed (U.S. National Library of Medicine)

• Macitentan: Endothelin receptor antagonist (ETA and ETB) that blocks endothelin-1 mediated vasoconstriction and proliferation.