سعر انفيجا سوستينا 100مجم/مل سرنجة معبأة للحقن العضل 2024

Invega Sustenna 100 mg/ml (Janssen-Cilag; Alza Corporation, USA): paliperidone 100 mg as an extended-release (prolonged-release) aqueous suspension of paliperidone palmitate in a single prefilled syringe for intramuscular injection; a long-acting atypical antipsychotic.

• Maintenance treatment of schizophrenia in adults stabilised with paliperidone or risperidone (or, in selected adults, without prior oral stabilisation).Population: AdultsEuropean Medicines Agency (EMA)
• Treatment of schizophrenia in adults; treatment of schizoaffective disorder in adults as monotherapy or as an adjunct to mood stabilisers or antidepressants.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common likely drug-related adverse reactions in schizophrenia trials: injection-site reactions, somnolence/sedation, dizziness, akathisia and extrapyramidal disorder.International label, same product · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to paliperidone, to risperidone or to any of the excipients.International label, same formulation · European Medicines Agency (EMA)
• Contraindicated in known hypersensitivity to paliperidone or risperidone or any excipient; anaphylactic reactions and angioedema have been reported with both.International label, same product · DailyMed (U.S. National Library of Medicine)

• Boxed warning: elderly patients with dementia-related psychosis treated with antipsychotics have an increased risk of death; Invega Sustenna is not approved for dementia-related psychosis.International label, same product · DailyMed (U.S. National Library of Medicine)
• Other label warnings: cerebrovascular adverse reactions in elderly dementia patients, neuroleptic malignant syndrome, QT prolongation, tardive dyskinesia, metabolic changes (hyperglycaemia/diabetes, dyslipidaemia, weight gain), orthostatic hypotension and syncope, falls, leukopenia/neutropenia/agranulocytosis, hyperprolactinaemia, cognitive and motor impairment, seizures, dysphagia, priapism and disrupted body temperature regulation.International label, same product · DailyMed (U.S. National Library of Medicine)

• Drugs that may cause orthostatic hypotensionThe US label lists drugs that may cause orthostatic hypotension as having a clinically important interaction (possible additive effect).DailyMed (U.S. National Library of Medicine)

• Published epidemiologic data have not established a paliperidone-associated risk of major birth defects, miscarriage or adverse maternal/fetal outcomes; untreated schizophrenia and antipsychotic exposure both carry maternal risks.International label, same product · DailyMed (U.S. National Library of Medicine)
• No adequate data on paliperidone use in pregnancy; paliperidone palmitate and oral paliperidone were not teratogenic in animals, but other reproductive toxicity was seen.International label, same formulation · European Medicines Agency (EMA)
• Paliperidone is excreted in breast milk to such an extent that effects on the breastfed infant are likely; it should not be used while breastfeeding.International label, same formulation · European Medicines Agency (EMA)

• Paliperidone (as paliperidone palmitate): Paliperidone is reported to act as an antagonist at dopamine D2, serotonin 5-HT2 and alpha1-adrenergic receptors (Egyptian directory pharmacology note).