سعر اميبرايد 400مجم 20 قرص 2024

Amisulpride 400 mg scored film-coated tablets, pack of 20 (2 strips); atypical antipsychotic for schizophrenia.

• Treatment of acute and chronic schizophrenic disorders with positive symptoms (delusions, hallucinations, thought disorders) and/or negative symptoms (blunted affect, emotional and social withdrawal), including when negative symptoms predominatePopulation: Adultselectronic medicines compendium (eMC)

• Very common: extrapyramidal disorders (tremor, rigidity, hypokinesia, hypersalivation, akathisia, dyskinesia). Common: acute dystonia, somnolence, insomnia, anxiety, agitation, orgasmic dysfunction, blurred vision, hypotension, constipation, nausea, vomiting, dry mouth, increased prolactin (galactorrhoea, amenorrhoea, gynaecomastia, breast pain, erectile dysfunction), weight gain. Rare: neuroleptic malignant syndrome, QT prolongation and torsade de pointes, agranulocytosis, venous thromboembolism.International label, same formulation · electronic medicines compendium (eMC)

• Hypersensitivity to amisulpride or excipients; concomitant prolactin-dependent tumours (e.g. pituitary prolactinoma, breast cancer); phaeochromocytoma; children before puberty; combination with levodopa.International label, same formulation · electronic medicines compendium (eMC)

• Neuroleptic malignant syndrome (stop treatment); dose-dependent QT prolongation - caution in bradycardia, hypokalaemia, congenital long QT or with QT-prolonging drugs; hyperglycaemia/metabolic effects; lowers seizure threshold; increased mortality and stroke risk in elderly patients with dementia; venous thromboembolism; hyperprolactinaemia (caution with breast cancer history; pituitary tumours); leukopenia, neutropenia and agranulocytosis; severe liver toxicity reported; avoid in Parkinson's disease unless essential; withdraw gradually to avoid withdrawal symptoms; contains lactose.International label, same formulation · electronic medicines compendium (eMC)

• LevodopaContraindicated: reciprocal antagonism between levodopa and neuroleptics.electronic medicines compendium (eMC)
• QT-prolonging drugs (class IA and III antiarrhythmics, some antihistamines, other antipsychotics, mefloquine) and drugs causing bradycardia or hypokalaemiaIncreased risk of QT prolongation and torsade de pointes; use with caution or avoid.electronic medicines compendium (eMC)
• Alcohol and other CNS depressants (narcotics, anaesthetics, analgesics, sedative antihistamines, barbiturates, benzodiazepines, clonidine)Enhanced central sedative effects; avoid alcohol.electronic medicines compendium (eMC)

• Limited human data; not recommended during pregnancy and in women of childbearing potential not using effective contraception, unless the benefit justifies the risk.International label, same formulation · electronic medicines compendium (eMC)
• Excreted into breast milk in relatively large amounts; decide whether to discontinue breastfeeding or abstain from amisulpride.International label, same formulation · electronic medicines compendium (eMC)

• Amisulpride: Binds selectively to dopaminergic D2 and D3 receptors; at low doses preferentially blocks presynaptic D2/D3 receptors, at higher doses postsynaptic receptors, particularly in the limbic system (UK SmPC).