سعر ايزوكيت 0.1% امبول وريد 2022

Isosorbide dinitrate 0.1% ampoule for intravenous infusion (Isoket), an organic nitrate vasodilator, supplied in Egypt by Hexal AG Germany > GlaxoSmithKline; sold as a single ampoule.

• Intravenous: unresponsive left ventricular failure secondary to acute myocardial infarction, unresponsive left ventricular failure of various aetiology, and severe or unstable angina pectoris.Population: Adultselectronic medicines compendium (emc), UK
• Intracoronary: during percutaneous transluminal coronary angioplasty to facilitate prolonged balloon inflation and to prevent or relieve coronary spasm.Population: Adultselectronic medicines compendium (emc), UK

• Very common: headache. Common: dizziness, somnolence, tachycardia, orthostatic hypotension, asthenia. Uncommon: aggravated angina, collapse (sometimes with bradyarrhythmia and syncope), nausea, vomiting, allergic skin reactions, flushing. Very rare: heartburn, angioedema, Stevens-Johnson syndrome. Not known: hypotension, exfoliative dermatitis. Transient hypoxaemia may occur.International label, same formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to isosorbide dinitrate, other nitrates or any excipient.International label, same formulation · electronic medicines compendium (emc), UK
• Nitrate-class contraindications: marked anaemia, cerebral haemorrhage, head trauma, raised intracranial pressure, hypovolaemia, severe hypotension (systolic < 90 mmHg), aortic and/or mitral valve stenosis, closed-angle glaucoma, circulatory collapse or low filling pressure.International label, same formulation · electronic medicines compendium (emc), UK
• Not to be used for cardiogenic shock (unless adequate diastolic pressure is maintained), hypertrophic obstructive cardiomyopathy, constrictive pericarditis or cardiac tamponade.International label, same formulation · electronic medicines compendium (emc), UK

• Use with caution and under medical supervision in hypothyroidism, malnutrition, severe liver or renal disease, hypothermia and orthostatic syndrome.International label, same formulation · electronic medicines compendium (emc), UK
• Tolerance and cross-tolerance to other nitrates can develop; continuously high doses should be avoided.International label, same formulation · electronic medicines compendium (emc), UK
• Acute isosorbide dinitrate therapy must not be used within 24 hours of sildenafil or vardenafil, or 48 hours of tadalafil.International label, same formulation · electronic medicines compendium (emc), UK

• Phosphodiesterase-5 inhibitors (sildenafil, tadalafil, vardenafil)Potentiate the hypotensive effect, possibly with life-threatening cardiovascular complications; contraindicated (no acute ISDN within 24 h of sildenafil/vardenafil or 48 h of tadalafil).electronic medicines compendium (emc), UK
• RiociguatConcomitant use contraindicated because it can cause hypotension.electronic medicines compendium (emc), UK
• Antihypertensives, vasodilators, neuroleptics, tricyclic antidepressants, MAO inhibitors, alcoholMay potentiate the hypotensive effect of Isoket.electronic medicines compendium (emc), UK

• No data indicate adverse effects in pregnancy, but safety has not been established; use only if the physician judges that benefits outweigh possible hazards. Animal studies showed no teratogenicity (post-implantation loss at high maternally toxic oral doses).International label, same formulation · electronic medicines compendium (emc), UK
• Evidence is inadequate to determine infant risk; nitrates are excreted in breast milk and may cause methaemoglobinaemia in infants; use with caution.International label, same formulation · electronic medicines compendium (emc), UK

• Isosorbide dinitrate: Organic nitrate vasodilator: lowers left and right ventricular end-diastolic pressures (mainly preload, also afterload), redistributes coronary blood flow towards ischaemic myocardium and reduces myocardial oxygen demand by increasing venous capacitance.