سعر ميجلوكون 850مجم 30 قرص 2022

Metformin hydrochloride 850 mg film-coated tablets, 30 tablets (3 strips).

• Adjunct to diet and exercise to improve glycemic control in type 2 diabetes mellitus.Population: Adults and pediatric patients 10 years and olderDailyMed (U.S. National Library of Medicine)

• More than 5% and more common than placebo: diarrhea 53%, nausea/vomiting 26%, flatulence 12%, asthenia 9%, indigestion 7%, abdominal discomfort 6%, headache 6%.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Severe renal impairment (eGFR below 30 ml/min/1.73 m2); hypersensitivity to metformin; acute or chronic metabolic acidosis, including diabetic ketoacidosis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning - lactic acidosis: postmarketing cases have been fatal. Risk factors include renal impairment, carbonic anhydrase inhibitors (e.g. topiramate), age 65 or older, radiological contrast, surgery, hypoxic states (e.g. acute heart failure), excessive alcohol, hepatic impairment. If suspected, stop metformin and give supportive care in hospital; prompt hemodialysis is recommended.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Vitamin B12 levels may fall (about 7% in trials); measure hematologic parameters yearly and vitamin B12 every 2-3 years.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypoglycemia risk increases when combined with insulin or insulin secretagogues (e.g. sulfonylureas); lower doses of these may be needed.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Carbonic anhydrase inhibitors (topiramate, zonisamide, acetazolamide, dichlorphenamide)May increase the risk of lactic acidosis; consider more frequent monitoring.DailyMed (U.S. National Library of Medicine)
• OCT2/MATE inhibitors (ranolazine, vandetanib, dolutegravir, cimetidine)May increase metformin exposure and lactic acidosis risk; weigh benefits and risks.DailyMed (U.S. National Library of Medicine)
• AlcoholPotentiates the effect of metformin on lactate metabolism; avoid excessive alcohol.DailyMed (U.S. National Library of Medicine)

• Limited data are not sufficient to determine a drug-associated risk; published studies have not shown a clear association with major birth defects or miscarriage; poorly controlled diabetes in pregnancy carries maternal and fetal risks.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Metformin is present in human milk (infant dose about 0.11-1% of the maternal weight-adjusted dose); effects on the infant are insufficiently known; weigh benefits and risks.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Metformin hydrochloride: Decreases hepatic glucose production, decreases intestinal glucose absorption and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.