سعر ايزوماك ريتارد 40 مجم 20 كبسولة 2024

Isosorbide dinitrate 40 mg prolonged-release (retard) capsules, an oral organic nitrate, made in Egypt by October Pharma; 20 capsules.

• Prevention of angina pectoris due to coronary artery disease; onset is not rapid enough to abort an acute anginal episode.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Headache (may be severe) is the most common adverse reaction; transient lightheadedness and hypotension (occasionally severe) occur; syncope, crescendo angina and rebound hypertension are uncommon; methaemoglobinaemia is extremely rare at usual doses.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Allergy to isosorbide dinitrate (allergic reactions to organic nitrates are extremely rare).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Sildenafil can amplify the vasodilatory effect and cause severe hypotension.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Benefits of extended-release oral isosorbide dinitrate in acute myocardial infarction or congestive heart failure are not established; because its effects are difficult to terminate rapidly, this formulation is not recommended in these settings.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Severe hypotension, particularly when upright, may occur even with small doses; use with caution in volume-depleted or hypotensive patients. Hypotension may be accompanied by paradoxical bradycardia and increased angina; nitrates may aggravate angina caused by hypertrophic cardiomyopathy.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Sildenafil (phosphodiesterase-5 inhibitor)Amplifies the vasodilatory effect; severe hypotension can result.DailyMed (U.S. National Library of Medicine)
• Other vasodilators, alcoholVasodilating effects may be additive; alcohol in particular shows additive effects.DailyMed (U.S. National Library of Medicine)

• Dose-related embryotoxicity was seen in rabbits at 35 and 150 times the maximum recommended human dose; there are no adequate, well-controlled studies in pregnant women; use only if the potential benefit justifies the potential risk to the fetus.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• It is not known whether isosorbide dinitrate is excreted in human milk; use with caution in nursing women.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Isosorbide dinitrate: Relaxes vascular smooth muscle and dilates peripheral veins more than arteries, reducing venous return and left ventricular end-diastolic pressure (preload) and, to a lesser extent, systemic vascular resistance (afterload); coronary arteries also dilate.