سعر اسمن ستادا 40 مجم ام ار 20 كبسولة 2022

ISMN Stada 40 mg (Global Napi Pharmaceuticals > Stada): isosorbide-5-mononitrate 40 mg modified-release oral capsules, pack of 20 (2 strips); an organic nitrate vasodilator used as an antianginal.

• Prophylactic treatment of angina pectoris in adults.Population: Adultselectronic medicines compendium (emc), UK
• Prevention of angina pectoris due to coronary artery disease (not for aborting an acute anginal episode).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Very common: headache (usually disappears after 1-2 weeks). Common: hypotension, orthostatic light-headedness (with flushing, dizziness, drowsiness, tachycardia, weakness), tachycardia. Uncommon: nausea, vomiting, collapse (sometimes with bradyarrhythmia and syncope), hyperhidrosis. Rare: restlessness, somnolence, paroxysmal bradycardia, heartburn. Not known: hypoxia, diarrhoea, pruritus, exfoliative dermatitis, rash, myalgia, asthenia.International label, same formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to isosorbide mononitrate, nitrates or excipients; acute myocardial infarction with low filling pressures; hypertrophic obstructive cardiomyopathy; constrictive pericarditis; cardiac tamponade; aortic/mitral stenosis; severe anaemia; hypovolaemia; raised intracranial pressure (e.g. cerebral haemorrhage, head trauma); closed-angle glaucoma; severe cerebrovascular insufficiency or hypotension; co-administration with phosphodiesterase type-5 inhibitors (e.g. sildenafil).International label, same formulation · electronic medicines compendium (emc), UK
• US label: contraindicated in patients with hypersensitivity or idiosyncratic reactions to other nitrates or nitrites.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Not for relief of acute angina attacks (use glyceryl trinitrate). Tolerance may develop with modified-release preparations; use the lowest effective dose and do not stop suddenly (taper dose and frequency). Circulatory collapse may occur after the first dose in patients with labile circulation; nitrate hypotension may be accompanied by paradoxical bradycardia and increased angina; severe postural hypotension may follow alcohol. Caution after recent myocardial infarction and in hypothyroidism, hypothermia, malnutrition, severe liver or renal disease, and cirrhosis. Contains lactose and sucrose (UK product).International label, same formulation · electronic medicines compendium (emc), UK

• Phosphodiesterase type-5 inhibitors (e.g. sildenafil)Markedly increased hypotensive effect that may lead to life-threatening cardiovascular complications; co-administration is contraindicated.electronic medicines compendium (emc), UK
• Alcohol, antihypertensives, vasodilators, calcium channel blockers, diureticsHypotensive effects may be potentiated; alcohol may also increase the release rate of the prolonged-release capsule.electronic medicines compendium (emc), UK
• DihydroergotamineIsosorbide mononitrate may increase dihydroergotamine blood levels and its hypertensive effect.electronic medicines compendium (emc), UK

• Safety in human pregnancy has not been established and animal studies have shown reproductive toxicity; use in pregnancy only if the physician considers the benefits outweigh the hazards.International label, same formulation · electronic medicines compendium (emc), UK
• It is not known whether nitrates are excreted in human milk; use during breastfeeding with caution and only if benefits outweigh hazards.International label, same formulation · electronic medicines compendium (emc), UK

• Isosorbide mononitrate: Organic nitrate vasodilator: venous dilatation reduces preload and myocardial oxygen demand; the active moiety is nitric oxide.